Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0227 | ||||
| Gene Name | SLC26A1 | ||||
| Protein Name | Sulfate anion transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | CAON; SAT-1; SAT1; SLC26A1; Solute carrier family 26 member 1 | ||||
| DT Family | Sulfate Permease (SULP) Family ; | ||||
| Tissue Specificity | Expressed most abundantly in the kidney andliver, with lower levels in the pancreas, testis, brain, smallintestine, colon, and lung. | ||||
| Function | This transporter mediates sulfate transport with high affinity, oxalate and bicarbonate. | ||||
| Endogenous Substrate(s) | Cl- | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sulfate anion transporter 1 |
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(β) Cell Distribution Level of Sulfate anion transporter 1 |
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(γ) Organelle Distribution Level of Sulfate anion transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sulfate anion transporter 1 |
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(γ) Transcriptional Regulation of Sulfate anion transporter 1 |
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(δ) Epigenetic Regulation of Sulfate anion transporter 1 |
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(ε) Exogenous Modulation of Sulfate anion transporter 1 |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sulfate anion transporter 1 |
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(β) Disease-specific Protein Abundances of Sulfate anion transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Clinical Trial Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Bicarbonate
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Phase 3 | Drug Info | Metabolic acidosis | 5C73 | [1] |
| References | |||||
| 1 | SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703. | ||||
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