| General Information of DT | |||||
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| DT ID | DTD0224 | ||||
| Gene Name | SLC25A7 | ||||
| Protein Name | Mitochondrial brown fat uncoupling protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:2LCK_A Identity:57.966% Minimized Score:-466.489 kcal/mol Detail: Structure Info |
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| Synonyms | SLC25A7; Solute carrier family 25 member 7; Thermogenin; UCP; UCP 1; UCP1 | ||||
| DT Family | Mitochondrial Carrier (MC) Family ; | ||||
| Tissue Specificity | Expressed in brown adipose tissue. | ||||
| Function | This transporter functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. | ||||
| Endogenous Substrate(s) | H+; Cl-; Fatty acids | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Mitochondrial brown fat uncoupling protein 1 |
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(β) Cell Distribution Level of Mitochondrial brown fat uncoupling protein 1 |
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(γ) Organelle Distribution Level of Mitochondrial brown fat uncoupling protein 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Mitochondrial brown fat uncoupling protein 1 |
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(γ) Transcriptional Regulation of Mitochondrial brown fat uncoupling protein 1 |
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(δ) Epigenetic Regulation of Mitochondrial brown fat uncoupling protein 1 |
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(ε) Exogenous Modulation of Mitochondrial brown fat uncoupling protein 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Mitochondrial brown fat uncoupling protein 1 |
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(β) Disease-specific Protein Abundances of Mitochondrial brown fat uncoupling protein 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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