General Information of Drug Transporter (DT)
DT ID	DTD0224 Transporter Info
Gene Name	SLC25A7
Transporter Name	Mitochondrial brown fat uncoupling protein 1
Gene ID	7350
UniProt ID	P25874
Modelled Structures of This DT
Click to Save PDB File in TXT Format
Detail Information of Structural Model
Method	Homology modeling
Template PDB	2LCK_A		Identity	57.966%
Performance	Minimized Score	-466.489 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	Medium
Ramachandran Plot
	Click to Save Ramachandran Plot in PNG Format
	Ramz Z Score	-1.58 ±0.44
	Residues in Favored Region	282	Ramachandran favored	97.58%
	Number of Outliers	3	Ramachandran outliers	1.04%
Local Quality
	Click to Save Local Quality Plot in PNG Format
	QMEANBrane Score		0.77
AlphaFold Protein Structure Database	P25874 Click to jump to the details page
SWISS-MODEL Database	P25874 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8G8W	EM	3.8 Å	Escherichia coli,Saccharomyces Cerevisiae	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	310		Mutation	No
8HBV	EM	2.51 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	363		Mutation	No
8HBW	EM	2.57 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	363		Mutation	No
8J1N	EM	2.51 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	363		Mutation	No
References
1	Structural basis of purine nucleotide inhibition of human uncoupling protein 1. Sci Adv. 2023;9(22):eadh4251.
2	Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature. 2023;620(7972):226-231.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.