Drug Transporter (DT) Information

General Information of DT
DT ID DTD0162
Gene Name SLC24A1
Protein Name Sodium/potassium/calcium exchanger 1
Gene ID
9187
UniProt ID
O60721
TCDB ID
2.A.19.4.9
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms CSNB1D; HsT17412; KIAA0702; NCKX; NCKX1; Na(+)/K(+)/Ca(2+)-exchange protein 1; RODX; Retinal rod Na-Ca+K exchanger; SLC24A1; Solute carrier family 24 member 1
DT Family Ca(2+):Cation Antiporter (CACA) Family ;
Tissue Specificity Expressed in the retina, particularly in theinner segment, outer and inner nuclear layers, and ganglion celllayer.
Function This transporter plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Endogenous Substrate(s) Ca2+; K+; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/potassium/calcium exchanger 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/potassium/calcium exchanger 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/potassium/calcium exchanger 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/potassium/calcium exchanger 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/potassium/calcium exchanger 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/potassium/calcium exchanger 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/potassium/calcium exchanger 1
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/potassium/calcium exchanger 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/potassium/calcium exchanger 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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