Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0162 Transporter Info
Gene Name SLC24A1
Transporter Name Sodium/potassium/calcium exchanger 1
Gene ID
9187
UniProt ID
O60721
Epigenetic Regulations of This DT (EGR)

Methylation

  Pancretic ductal adenocarcinoma

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC24A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 5'UTR (cg22374485)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:4.81E+00 Statistic Test p-value:6.75E-36; Z-score:1.84E+01

Methylation in Case

 2.95E-01 (Median) Methylation in Control 6.13E-02 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC24A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 TSS200 (cg19876838)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:3.92E-07; Z-score:-1.23E+00

Methylation in Case

 8.02E-01 (Median) Methylation in Control 8.29E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC24A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 TSS200 (cg04230910)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.52E+00 Statistic Test p-value:9.43E-05; Z-score:-5.98E-01

Methylation in Case

 7.57E-02 (Median) Methylation in Control 1.15E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC24A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 Body (cg08831522)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.10E+00 Statistic Test p-value:9.05E-03; Z-score:7.68E-01

Methylation in Case

 8.29E-01 (Median) Methylation in Control 7.56E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Bladder cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC24A1 in bladder cancer [ 2 ]

Location

 TSS1500 (cg00431427)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.15E+00 Statistic Test p-value:9.56E-04; Z-score:-8.20E+00

Methylation in Case

 7.40E-01 (Median) Methylation in Control 8.51E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC24A1 in bladder cancer [ 2 ]

Location

 Body (cg18193482)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.21E+00 Statistic Test p-value:2.28E-05; Z-score:5.54E+00

Methylation in Case

 8.93E-01 (Median) Methylation in Control 7.36E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Breast cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC24A1 in breast cancer [ 3 ]

Location

 TSS1500 (cg00431427)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:6.91E-08; Z-score:-1.48E+00

Methylation in Case

 7.96E-01 (Median) Methylation in Control 8.46E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC24A1 in breast cancer [ 3 ]

Location

 TSS1500 (cg07116160)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:2.51E-02; Z-score:-7.02E-01

Methylation in Case

 8.64E-01 (Median) Methylation in Control 8.89E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC24A1 in breast cancer [ 3 ]

Location

 Body (cg01704999)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.11E+00 Statistic Test p-value:7.43E-05; Z-score:6.76E-01

Methylation in Case

 1.09E-01 (Median) Methylation in Control 9.77E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC24A1 in breast cancer [ 3 ]

Location

 Body (cg18193482)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:1.30E-03; Z-score:-9.57E-01

Methylation in Case

 8.80E-01 (Median) Methylation in Control 9.09E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            5 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC24A1 in colorectal cancer [ 4 ]

Location

 TSS1500 (cg00431427)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.07E+00 Statistic Test p-value:7.28E-09; Z-score:-3.30E+00

Methylation in Case

 8.40E-01 (Median) Methylation in Control 9.00E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC24A1 in colorectal cancer [ 4 ]

Location

 Body (cg18193482)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.02E+00 Statistic Test p-value:6.02E-04; Z-score:9.74E-01

Methylation in Case

 9.21E-01 (Median) Methylation in Control 9.04E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC24A1 in colorectal cancer [ 4 ]

Location

 Body (cg01704999)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.07E+00 Statistic Test p-value:1.11E-03; Z-score:5.38E-01

Methylation in Case

 1.93E-01 (Median) Methylation in Control 1.81E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Epigenetic regulation in BRAF-mutated CRC [ 7 ]

Location

 Genome-wide

Epigenetic Type

 Methylation Experiment Method Metabolomics & epigenomic profiling

Studied Phenotype

 Colorectal cancer[ ICD-11:2B90]

Experimental Material

 39 MSS BRAF-mutated CRC tumors

Additional Notes

 SLC24A1 is implicated in the hypermethylation phenotype of microsatellite-stable BRAF-mutated CRC. Low vitamin C levels (regulated by SLC23A1) may reduce TET demethylase activity, contributing to global hypermethylation.

  Hepatocellular carcinoma

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC24A1 in hepatocellular carcinoma [ 5 ]

Location

 TSS1500 (cg00431427)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:5.51E-07; Z-score:-1.48E+00

Methylation in Case

 7.86E-01 (Median) Methylation in Control 8.33E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC24A1 in hepatocellular carcinoma [ 5 ]

Location

 TSS1500 (cg14601251)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.02E+00 Statistic Test p-value:2.95E-05; Z-score:-9.37E-01

Methylation in Case

 8.45E-01 (Median) Methylation in Control 8.64E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC24A1 in hepatocellular carcinoma [ 5 ]

Location

 TSS1500 (cg20330315)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:4.20E-03; Z-score:-5.00E-01

Methylation in Case

 8.49E-01 (Median) Methylation in Control 8.61E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC24A1 in papillary thyroid cancer [ 6 ]

Location

 TSS1500 (cg14601251)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.10E+00 Statistic Test p-value:2.19E-05; Z-score:2.18E+00

Methylation in Case

 8.98E-01 (Median) Methylation in Control 8.14E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Lymphoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Moderate hypomethylation of SLC24A1 in lymphoma than that in healthy individual

Studied Phenotype

 Lymphoma [ICD-11:2B30]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:2.23E-10; Fold-change:-0.280112254; Z-score:-1.861762716
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Esthesioneuroblastoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypomethylation of SLC24A1 in esthesioneuroblastoma than that in healthy individual

Studied Phenotype

 Esthesioneuroblastoma [ICD-11:2D50.1]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:1.71E-07; Fold-change:-0.39108765; Z-score:-2.515422902
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Medulloblastoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypomethylation of SLC24A1 in medulloblastoma than that in healthy individual

Studied Phenotype

 Medulloblastoma [ICD-11:2A00.10]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:2.08E-41; Fold-change:-0.342164428; Z-score:-1.90683029
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Multilayered rosettes embryonal tumour

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypomethylation of SLC24A1 in multilayered rosettes embryonal tumour than that in healthy individual

Studied Phenotype

 Multilayered rosettes embryonal tumour [ICD-11:2A00.1]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:6.93E-20; Fold-change:-0.44643774; Z-score:-3.110669103
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual
References
1 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
2 DNA Methylation Dynamics in Urological Tumors.
3 Genome-wide Scan for Methylation Profiles in Breast Cancer
4 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
5 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
6 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
7 Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer. Oncogene. 2025 Jun;44(22):1718-1730.

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