Drug Transporter (DT) Information

General Information of DT
DT ID DTD0145
Gene Name SLC22A20
Protein Name Organic anion transporter 6
Gene ID
440044
UniProt ID
A6NK97
TCDB ID
2.A.1.19.35
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms SLC22A20; SLC22A20P; OAT6; Solute carrier family 22 member 20; Solute carrier family 22 member 20 pseudogene
DT Family Major Facilitator Superfamily (MFS)
Organic Cation Transporter (OCT) Family
Function This transporter is organic anion transporter that mediates the uptake of estrone sulfate.
Endogenous Substrate(s) Organic anions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Organic anion transporter 6
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Organic anion transporter 6
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Organic anion transporter 6
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Organic anion transporter 6
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Organic anion transporter 6
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Organic anion transporter 6
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Organic anion transporter 6
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Organic anion transporter 6
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Organic anion transporter 6
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Estrone sulfate
 Approved Drug Info Menopausal symptoms MF32 [1]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:         44 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
Estrone sulfate Approved Drug Info Chinese hamster ovary (CHO) cells-mOat6 Km =44.8 microM [1]
Estrone sulfate Approved Drug Info Oocytes-mOat6 Km =109.8 microM [1]
References
1 Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol. 2006 Aug;291(2):F314-21.

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