Drug Transporter (DT) Information

General Information of DT
DT ID DTD0121
Gene Name SLC17A8
Protein Name Vesicular glutamate transporter 3
Gene ID
246213
UniProt ID
Q8NDX2
TCDB ID
2.A.1.14.32
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6V4D_A

Identity:78.447%

Minimized Score:-1082.495 kcal/mol

Detail: Structure Info

Synonyms DFNA25; SLC17A8; Solute carrier family 17 member 8; VGluT3
DT Family Major Facilitator Superfamily (MFS)
Anion:Cation Symporter (ACS) Family
Tissue Specificity Expressed in amygdala, cerebellum,hippocampus, medulla, spinal cord and thalamus.
Function This transporter may mediate the transport of inorganic phosphate and the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells.
Endogenous Substrate(s) Glutamate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Vesicular glutamate transporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Vesicular glutamate transporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Vesicular glutamate transporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Vesicular glutamate transporter 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Vesicular glutamate transporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Vesicular glutamate transporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Vesicular glutamate transporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Vesicular glutamate transporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Vesicular glutamate transporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-glutamic acid
 Approved Drug Info Schizophrenia 6A20 [1]
References
1 Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65.

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