Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
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| DT ID | DTD0106 | ||||
| Gene Name | SLC16A2 | ||||
| Protein Name | Monocarboxylate transporter 8 | ||||
| Gene ID | |||||
| UniProt ID | |||||
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| 3D Structure |
Modelled DT Structure Method: multi-sequence alignment based machine learning Detail: Structure Info |
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| Synonyms | AHDS; DXS128; DXS128E; MCT 8; MCT8; MRX22; Monocarboxylate transporter 7; SLC16A2; Solute carrier family 16 member 2; X-linked PEST-containing transporter; XPCT | ||||
| DT Family | Major Facilitator Superfamily (MFS) | ||||
| Monocarboxylate Transporter (MCT) Family | |||||
| Tissue Specificity | Highly expressed in liver and heart. | ||||
| Function | This transporter is a very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. It does not transport Leu, Phe, Trp or Tyr. | ||||
| Endogenous Substrate(s) | Thyroid hormones | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Monocarboxylate transporter 8 |
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(β) Cell Distribution Level of Monocarboxylate transporter 8 |
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(γ) Organelle Distribution Level of Monocarboxylate transporter 8 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Monocarboxylate transporter 8 |
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(γ) Transcriptional Regulation of Monocarboxylate transporter 8 |
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(δ) Epigenetic Regulation of Monocarboxylate transporter 8 |
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(ε) Exogenous Modulation of Monocarboxylate transporter 8 |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Monocarboxylate transporter 8 |
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(β) Disease-specific Protein Abundances of Monocarboxylate transporter 8 |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.