Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0106 Transporter Info
Gene Name SLC16A2
Transporter Name Monocarboxylate transporter 8
Gene ID
6567
UniProt ID
P36021

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to SLC16A2 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC16A2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 8.

      Class1.3: Basic helix-span-helix factors

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        TFAP2A 

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       Transcriptional Phenomenon1

 Binding to SLC16A2 gene in MCF7 cells [2]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC16A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Monocarboxylate transporter 8.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        RARA 

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       Transcriptional Phenomenon1

 Activation of SLC16A2 gene in teratocarcinoma condition [3]

TF Protein Name

 Retinoic acid receptor alpha Transcription Factor Info

Studied Phenotype

 Teratocarcinoma [ICD11: 2C12.0Y]

Tissue

 Embryo

Related DT Changes

 Up regulating

Experimental Material

 Mouse teratocarcinoma cells (F9)

Detailed Description

 Retinoic acid receptor alpha (RARA) has been reported to activate the transcription of SLC16A2 gene in teratocarcinoma condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 8.

      Class2.3: C2H2 zinc finger factors

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        KLF4 

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       Transcriptional Phenomenon1

 Direct binding to SLC16A2 gene [4]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Breast; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC16A2 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 8.

        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC16A2 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A2 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 8.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Binding to SLC16A2 gene in MCF7 condition [6]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC16A2 gene in MCF7 condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 8.

        FOXP1 

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       Transcriptional Phenomenon1

 Direct binding to SLC16A2 gene [7]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC16A2 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 8.

      Class3.5: Tryptophan cluster factors

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        ETS1 

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       Transcriptional Phenomenon1

 Direct binding to SLC16A2 gene [8]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Kidney; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC16A2 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 8.

        SPI1 

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       Transcriptional Phenomenon1

 Binding to SLC16A2 gene in acute myeloid leukemia condition [9]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC16A2 gene in acute myeloid leukemia condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 8.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC16A2 gene in epithelial to mesenchymal transition condition [10]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC16A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 8.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC16A2 gene in epithelial ovarian cancer condition [11]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC16A2 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 8.
References
1 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
2 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
3 Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8). J Biol Chem. 2010 Aug 27;285(35):27279-27288.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
7 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
8 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-319. (ID:ENSG00000147100)
9 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
10 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
11 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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