Drug Transporter (DT) Information

General Information of DT
DT ID DTD0054
Gene Name ABCB8
Protein Name ATP-binding cassette sub-family B member 8
Gene ID
11194
UniProt ID
Q9NUT2
TCDB ID
3.A.1.201.22
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:5OCH_A

Identity:99.835%

Minimized Score:-1629.298 kcal/mol

Detail: Structure Info

Synonyms ABCB8; EST328128; M-ABC1; MABC1; Mitochondrial ATP-binding cassette 1
DT Family ATP-Binding Cassette (ABC) Superfamily
Multidrug Resistance Exporter (MDR) Family (ABCB)
Tissue Specificity Ubiquitous.
Function This transporter is a complex, integral component of membrane, membrane, mitochondrial envelope, mitochondrion, nucleolus, nucleus, ATP binding, ATPase activity, coupled to transmembrane movement of substances, transporter activity.
Endogenous Substrate(s) Peptides
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family B member 8
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family B member 8
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family B member 8
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of ATP-binding cassette sub-family B member 8
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family B member 8
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family B member 8
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family B member 8
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family B member 8
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family B member 8
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Doxorubicin
 Approved Drug Info Leukemia 2A60-2B33 [1]
References
1 ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol Cancer Res. 2009 Jan;7(1):79-87.

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