Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0054 Transporter Info
Gene Name	ABCB8
Transporter Name	ATP-binding cassette sub-family B member 8
Gene ID	11194
UniProt ID	Q9NUT2

Post-Translational Modification of This DT
Overview ofABCB8 Modification Sites with Functional and Structural Information
Sequence	M L V H L F R V G I R G G P F P G R L L P P L R F Q T F S A V R N T W R N G K T G Q L H K A E G E Y S D G Y R S S S L L R A V A H L R S Q L W A H L P R A P L A P R W S P S A W C W V G G A L L G P M V L S K H P H L C L V A L C E A E E A P P A S S T P H V V G S R F N W K L F W Q F L H P H L L V L G V A V V L A L G A A L V N V Q I P L L L G Q L V E V V A K Y T R D H V G S F M T E S Q N L S T H L L I L Y G V Q G L L T F G Y L V L L S H V G E R M A V D M R R A L F S S L L R Q D I T F F D A N K T G Q L V S R L T T D V Q E F K S S F K L V I S Q G L R S C T Q V A G C L V S L S M L S T R L T L L L M V A T P A L M G V G T L M G S G L R K L S R Q C Q E Q I A R A M G V A D E A L G N V R T V R A F A M E Q R E E E R Y G A E L E A C R C R A E E L G R G I A L F Q G L S N I A F N C M V L G T L F I G G S L V A G Q Q L T G G D L M S F L V A S Q T V Q R S M A N L S V L F G Q V V R G L S A G A R V F E Y M A L N P C I P L S G G C C V P K E Q L R G S V T F Q N V C F S Y P C R P G F E V L K D F T L T L P P G K I V A L V G Q S G G G K T T V A S L L E R F Y D P T A G V V M L D G R D L R T L D P S W L R G Q V V G F I S Q E P V L F G T T I M E N I R F G K L E A S D E E V Y T A A R E A N A H E F I T S F P E G Y N T V V G E R G T T L S G G Q K Q R L A I A R A L I K Q P T V L I L D E A T S A L D A E S E R V V Q E A L D R A S A G R T V L V I A H R L S T V R G A H C I V V M A D G R V W E A G T H E E L L K K G G L Y A E L I R R Q A L D A P R T A A P P P K K P E G P R S H Q H K S
PTM type	X-Acetylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB8			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB8 Lysine has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB8			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	323
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCB8 Cystine 323 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	233
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 233 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	544
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 544 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	544
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 544 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 577 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 577 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 577 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Serine 577 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	540
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Threonine 540 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	540
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB8 Threonine 540 has the potential to affect its expression or activity.
Ubiquitination
Lysine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB8			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	247
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 247 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB8			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	263
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 263 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	465
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 465 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB8			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 513 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB8			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	573
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 573 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCB8			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	628
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 628 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	699
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB8 Lysine 699 has the potential to affect its expression or activity.

References
1	Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep. 2012 Aug 30;2(2):419-31.
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
4	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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Detail Information of Post-Translational Modifications

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