Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0533 Transporter Info
Gene Name ATP7B
Transporter Name Copper-transporting ATPase 2
Gene ID
540
UniProt ID
P35670

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

      Class1.3: Basic helix-span-helix factors

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        TFAP2C 

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       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [2]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        ESR1 

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       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [3]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        HNF4G 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [5]

TF Protein Name

 Hepatocyte nuclear factor 4-gamma Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [2]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [2]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ATP7B gene in health condition [6]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of ATP7B gene in health condition, which leads to an increased expression of the drug transporter Copper-transporting ATPase 2.

      Class2.3: C2H2 zinc finger factors

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        CTCF 

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       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        MTF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ATP7B gene in hepatoblastoma condition [7]

TF Protein Name

 Metal regulatory transcription factor 1 Transcription Factor Info

Studied Phenotype

 Hepatoblastoma [ICD11: 2C12.01]

Tissue

 Liver

Related DT Changes

 up regulating

Experimental Material

 Human hepatoblastoma cells (HepG2)

Detailed Description

 Metal regulatory transcription factor 1 (MTF1), influenced by the exogenous cupric oxide, has been reported to activate the transcription of ATP7B gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter Copper-transporting ATPase 2.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [1]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CUX1 

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       Transcriptional Phenomenon1

 Activation of ATP7B gene in multiple human cancer types condition [8]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of ATP7B gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Copper-transporting ATPase 2.

        NANOG 

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       Transcriptional Phenomenon1

 Binding to ATP7B gene in health condition [9]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of ATP7B gene in health condition, which leads to an affected expression of the drug transporter Copper-transporting ATPase 2.

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [5]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

      Class3.3: Fork head / winged helix factors

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        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ATP7B gene in health condition [10]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of ATP7B gene in health condition, which leads to an affected expression of the drug transporter Copper-transporting ATPase 2.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [5]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ATP7B gene [4]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ATP7B gene in . condition, which leads to an affected expression of the drug transporter Copper-transporting ATPase 2.

      Class3.5: Tryptophan cluster factors

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        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [3]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ATP7B gene in megakaryocytes condition [11]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of ATP7B gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Copper-transporting ATPase 2.

       Transcriptional Phenomenon2

 Direct binding to ATP7B gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [1]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

      Class3.7: ARID domain factors

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        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ATP7B gene [3]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the ATP7B gene, which in turn affects the expression or function of the drug transporter Copper-transporting ATPase 2.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ATP7B gene in prostate cancer condition [12]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ATP7B gene in prostate cancer condition, which leads to an increased expression of the drug transporter Copper-transporting ATPase 2.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-247. (ID:ENSG00000123191)
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
7 Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions. Nanoscale. 2014;6(3):1707-15.
8 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
9 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
10 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
11 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
12 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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