Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0530 Transporter Info
Gene Name CACNA1H
Transporter Name Voltage-gated calcium channel alpha Cav3.2
Gene ID
8912
UniProt ID
O95180

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1H gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the CACNA1H gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1H gene [2]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the CACNA1H gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1H gene [3]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the CACNA1H gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1H gene in melanoma condition [4]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of CACNA1H gene in melanoma condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1H gene in medulloblastoma condition [5]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of CACNA1H gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1H gene in megakaryocytes condition [6]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of CACNA1H gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1H gene [7]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the CACNA1H gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

        EGR1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1H gene in erythroleukemia condition [8]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of CACNA1H gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

       Transcriptional Phenomenon2

 Activation of CACNA1H gene in glioblastoma condition [9]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 Glioblastoma [ICD11: 2A00.00]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Mouse glioblastoma cells (NG108-15)

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to activate the transcription of CACNA1H gene in glioblastoma condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

        REST 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1H gene in glioblastoma condition [9]

TF Protein Name

 RE1-silencing transcription factor Transcription Factor Info

Studied Phenotype

 Glioblastoma [ICD11: 2A00.00]

Tissue

 Brain

Related DT Changes

 Down regulating

Experimental Material

 mice

Detailed Description

 RE1-silencing transcription factor (REST) has been reported to repress the transcription of CACNA1H gene in glioblastoma condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1H gene in podocyte condition [10]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of CACNA1H gene in podocyte condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1H gene in health condition [11]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of CACNA1H gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1H gene in megakaryocytes condition [6]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of CACNA1H gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav3.2.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-438. (ID:ENSG00000196557)
4 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
5 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
6 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
7 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
9 Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J Biol Chem. 2012 May 4;287(19):15489-501.
10 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
11 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.

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