Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0526 Transporter Info
Gene Name SCN1A
Transporter Name Voltage-gated sodium channel alpha Nav1.1
Gene ID
6323
UniProt ID
P35498

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SCN1A gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SCN1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated sodium channel alpha Nav1.1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

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        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SCN1A gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SCN1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated sodium channel alpha Nav1.1.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

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        ERG 

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       Transcriptional Phenomenon1

 Binding to SCN1A gene in oncogenesis condition [3]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional regulator ERG (ERG) has been reported to bind to the transcription of SCN1A gene in oncogenesis condition, which leads to an affected expression of the drug transporter Voltage-gated sodium channel alpha Nav1.1.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SCN1A gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Brain; Embryo; Foreskin; Heart; Kidney; Lung; Muscle; Penis; Renal cortex; Renal pelvis; Skin; Spinal cord; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SCN1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated sodium channel alpha Nav1.1.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SCN1A gene in glioblastoma multiforme condition [5]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SCN1A gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Voltage-gated sodium channel alpha Nav1.1.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-309. (ID:ENSG00000144285)
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.

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