Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0502 Transporter Info
Gene Name	SLCO4A1
Transporter Name	Organic anion transporting polypeptide 4A1
Gene ID	28231
UniProt ID	Q96BD0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLCO4A1 gene in health condition			[5]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Wistar rats
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLCO4A1 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4A1.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLCO4A1 gene in melanoma condition			[6]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLCO4A1 gene in melanoma condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4A1.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Cervix; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLCO4A1 gene in prostate cancer condition			[7]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of SLCO4A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4A1.
Transcriptional Phenomenon2	Binding to SLCO4A1 gene in prostate cancer condition			[8]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLCO4A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4A1.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLCO4A1 gene in health condition			[9]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLCO4A1 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4A1.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLCO4A1 gene in atherosclerotic condition			[10]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLCO4A1 gene in atherosclerotic condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4A1.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast; Epithelium; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
EGR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLCO4A1 gene in erythroleukemia condition			[11]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLCO4A1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4A1.
Transcriptional Phenomenon2	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Colon; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLCO4A1 gene in podocyte condition			[12]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLCO4A1 gene in podocyte condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4A1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
HOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Homeobox protein Hox-A1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Hox-A1 (HOXA1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
E2F3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Transcription factor E2F3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F3 (E2F3) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLCO4A1 gene in health condition			[9]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLCO4A1 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4A1.
Transcriptional Phenomenon2	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
FOXP2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Forkhead box protein P2		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P2 (FOXP2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Breast; Liver; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
ELK1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLCO4A1 gene in health condition			[13]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of SLCO4A1 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4A1.
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Pancreas; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	GastroIntestine tract; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[3]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.3: SAND domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GMEB2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[1]
TF Protein Name	Glucocorticoid modulatory element-binding protein 2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Glucocorticoid modulatory element-binding protein 2 (GMEB2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[4]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLCO4A1 gene in HFKS condition			[14]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLCO4A1 gene in HFKS condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4A1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLCO4A1 gene in prostate cancer condition			[15]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLCO4A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4A1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLCO4A1 gene			[2]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLCO4A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4A1.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-185. (ID:ENSG00000101187)
2	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease. J Pharm Sci. 2011 Sep;100(9):3696-707.
6	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
7	Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
8	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
9	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10	Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
11	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
12	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
13	ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8(5):e1002694.
14	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
15	Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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