Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0494 Transporter Info
Gene Name SLC9A9
Transporter Name Sodium/hydrogen exchanger 9
Gene ID
285195
UniProt ID
Q8IVB4

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        BATF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [1]

TF Protein Name

 Basic leucine zipper transcriptional factor ATF-like Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

      Class1.2: Basic helix-loop-helix factors

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        HIF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A9 gene in hypoxia condition [3]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC9A9 gene in hypoxia condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 9.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A9 gene in glioblastoma multiforme condition [4]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC9A9 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 9.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in prostate cancer condition [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC9A9 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in megakaryocytes condition [6]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC9A9 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A9 gene in podocyte condition [7]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC9A9 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 9.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A9 gene in multiple human cancer types condition [8]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC9A9 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 9.

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A9 gene in embryonic stem cells condition [9]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC9A9 gene in embryonic stem cells condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 9.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in prostate cancer condition [10]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC9A9 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.

       Transcriptional Phenomenon2

 Direct binding to SLC9A9 gene [11]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

      Class3.5: Tryptophan cluster factors

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        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [12]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Tissue

 Brain; Breast; Colon; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in megakaryocytes condition [6]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC9A9 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [11]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Brain; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [1]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

        IRF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [2]

TF Protein Name

 Interferon regulatory factor 4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 4 (IRF4) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in HESC condition [13]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC9A9 gene in HESC condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in epithelial to mesenchymal transition condition [14]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC9A9 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [1]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

      Class6.5: T-Box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TBX21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [12]

TF Protein Name

 T-box transcription factor TBX21 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 T-box transcription factor TBX21 (TBX21) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A9 gene [12]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the SLC9A9 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 9.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A9 gene in epithelial ovarian cancer condition [15]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC9A9 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 9.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-417. (ID:ENSG00000181804)
3 High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 2011;117(23):e207-17.
4 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
5 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
6 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
7 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
8 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
9 Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
10 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
11 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
12 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
13 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
14 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
15 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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