Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0362 Transporter Info
Gene Name	SLC43A3
Transporter Name	Equilibrative nucleobase transporter 1
Gene ID	29015
UniProt ID	Q8NBI5

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Breast; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
LYL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Protein lyl-1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein lyl-1 (LYL1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in melanoma condition			[5]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC43A3 gene in melanoma condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
MYC		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC43A3 gene in Burkitt lymphoma condition			[6]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC43A3 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc proto-oncogene protein (MYC) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in Coronary Artery Disease (CAD) condition			[7]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the SLC43A3 gene in Coronary Artery Disease (CAD) condition, which affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[8]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in atherosclerotic condition			[9]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	T0901317
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC43A3 gene in atherosclerotic condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in myofibroblasts condition			[10]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Related DT Changes	Up regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of SLC43A3 gene in myofibroblasts condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in hematopoiesis condition			[11]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC43A3 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Activation of SLC43A3 gene in health condition			[12]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to activate the transcription of SLC43A3 gene in health condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon3	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
GATA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in hematopoiesis condition			[11]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC43A3 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood; Bone marrow; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Breast; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in CMLJURLMK1 condition			[13]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC43A3 gene in CMLJURLMK1 condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
SALL4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in health condition			[14]
TF Protein Name	Sal-like protein 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLC43A3 gene in health condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
PBX1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in ovarian cancer condition			[15]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC43A3 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
POU2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	POU domain, class 2, transcription factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
E2F3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Transcription factor E2F3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F3 (E2F3) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in health condition			[16]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC43A3 gene in health condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
FOXA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in prostate cancer condition			[17]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC43A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
TFDP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Transcription factor Dp-1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Dp-1 (TFDP1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class3.4: Heat shock factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
HSF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Heat shock factor protein 2		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Heat shock factor protein 2 (HSF2) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene			[18]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC43A3 gene in . condition, which leads to a affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[4]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
ELK3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in hypoxia condition			[19]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC43A3 gene in hypoxia condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[1]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Umbilical cord blood; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Brain; Liver; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
IRF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Interferon regulatory factor 4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 4 (IRF4) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in APL condition			[20]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC43A3 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC43A3 gene			[1]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[2]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC43A3 gene in colorectal cancer condition			[21]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC43A3 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Equilibrative nucleobase transporter 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[3]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC43A3 gene in health condition			[22]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC43A3 gene in health condition, which leads to an affected expression of the drug transporter Equilibrative nucleobase transporter 1.
Transcriptional Phenomenon2	Binding to SLC43A3 gene in megakaryocytes condition			[23]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC43A3 gene in megakaryocytes condition, which leads to a affected expression of the drug transporter Equilibrative nucleobase transporter 1.
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC43A3 gene			[4]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 2 (RUNX2) can directly bind to the SLC43A3 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleobase transporter 1.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-271. (ID:ENSG00000134802)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6	Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
7	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
8	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9	Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
10	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
11	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
12	Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol. 2012;32(1):226-39.
13	The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
14	SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
15	Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
16	Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
17	Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
18	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
19	The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
20	Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
21	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
22	Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.
23	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Transcriptional Regulations

Visitor Map

Correspondence