Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0354 Transporter Info | ||||
Gene Name | SLC41A1 | ||||
Transporter Name | Magnesium transporter protein solute carrier family 41 member 1 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
FOS |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
Protein c-Fos | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein c-Fos (FOS) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class1.2: Basic helix-loop-helix factors |
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BHLHE40 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
Class E basic helix-loop-helix protein 40 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
MYOD1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Myoblast determination protein 1 | Transcription Factor Info | ||||
Tissue |
Myotube | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myoblast determination protein 1 (MYOD1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
TCF4 |
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Transcriptional Phenomenon1 |
Binding to SLC41A1 gene in glioblastoma multiforme condition | [4] | ||||
TF Protein Name |
Transcription factor 4 | Transcription Factor Info | ||||
Affected Drug/Substrate |
Temozolomide | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC41A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
TFAP4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Transcription factor AP-4 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-4 (TFAP4) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
USF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Upstream stimulatory factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Brain; Embryo; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Upstream stimulatory factor 1 (USF1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
USF2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
Upstream stimulatory factor 2 | Transcription Factor Info | ||||
Tissue |
Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Upstream stimulatory factor 2 (USF2) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class1.3: Basic helix-span-helix factors |
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TFAP2C |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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AR |
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Transcriptional Phenomenon1 |
Binding to SLC41A1 gene in prostate cancer condition | [6] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Androgen receptor (AR) has been reported to bind to the transcription of SLC41A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
HNF4A |
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Transcriptional Phenomenon1 |
Binding to SLC41A1 gene in health condition | [7] | ||||
TF Protein Name |
Hepatocyte nuclear factor 4-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC41A1 gene in health condition, which leads to an affected expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
NR2F2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
COUP transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
COUP transcription factor 2 (NR2F2) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
PPARD |
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Transcriptional Phenomenon1 |
Repression of SLC41A1 gene in myofibroblast condition | [8] | ||||
TF Protein Name |
Peroxisome proliferator-activated receptor delta | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC41A1 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class2.3: C2H2 zinc finger factors |
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BCL6 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
B-cell lymphoma 6 protein | Transcription Factor Info | ||||
Tissue |
Tonsil | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
EGR1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Early growth response protein 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Early growth response protein 1 (EGR1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
KLF4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
Krueppel-like factor 4 | Transcription Factor Info | ||||
Tissue |
Foreskin; Pancreatic ductal; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 4 (KLF4) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
KLF5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Krueppel-like factor 5 | Transcription Factor Info | ||||
Tissue |
Pancreatic ductal; Stomach | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 5 (KLF5) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
ZNF143 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
Zinc finger protein 143 | Transcription Factor Info | ||||
Tissue |
Cervix; Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 143 (ZNF143) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class3.1: Homeo domain factors |
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NANOG |
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Transcriptional Phenomenon1 |
Activation of SLC41A1 gene in HESC condition | [9] | ||||
TF Protein Name |
Homeobox protein NANOG | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC41A1 gene in HESC condition, which leads to an increased expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
PBX1 |
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Transcriptional Phenomenon1 |
Activation of SLC41A1 gene in ovarian cancer condition | [10] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC41A1 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
E2F6 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
Transcription factor E2F6 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F6 (E2F6) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
FOXA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class3.5: Tryptophan cluster factors |
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ETS1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
Protein C-ets-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Kidney; Prostate; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-1 (ETS1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
FLI1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
GABPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Brain; Liver; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
IRF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Interferon regulatory factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Pancreatic ductal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Interferon regulatory factor 1 (IRF1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
SPI1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
SPIB |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [1] | ||||
TF Protein Name |
Transcription factor Spi-B | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Spi-B (SPIB) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class5.3: SAND domain factors |
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GMEB2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [3] | ||||
TF Protein Name |
Glucocorticoid modulatory element-binding protein 2 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Glucocorticoid modulatory element-binding protein 2 (GMEB2) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold |
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Class7.1: SMAD/NF-1 DNA-binding domain factors |
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SMAD4 |
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Transcriptional Phenomenon1 |
Binding to SLC41A1 gene in epithelial ovarian cancer condition | [11] | ||||
TF Protein Name |
Mothers against decapentaplegic homolog 4 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC41A1 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class8.1: TATA-binding proteins |
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TBP |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [5] | ||||
TF Protein Name |
TATA-box-binding protein | Transcription Factor Info | ||||
Tissue |
Bone marrow; Cervix; Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
TATA-box-binding protein (TBP) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
Class10.1: Other factors |
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GTF2B |
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Transcriptional Phenomenon1 |
Direct binding to SLC41A1 gene | [2] | ||||
TF Protein Name |
Transcription initiation factor IIB | Transcription Factor Info | ||||
Tissue |
Cervix; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription initiation factor IIB (GTF2B) can directly bind to the SLC41A1 gene, which in turn affects the expression or function of the drug transporter Magnesium transporter protein solute carrier family 41 member 1. | |||||
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