Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0336 Transporter Info
Gene Name SLC38A9
Transporter Name Sodium-coupled neutral amino acid transporter 9
Gene ID
153129
UniProt ID
Q8NBW4

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        ATF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A9 gene in amino acid deprivation condition [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-4 Transcription Factor Info

Studied Phenotype

 Amino acid deprivation [ICD11: 5C50]

Tissue

 Skeletal muscle

Related DT Changes

 Up regulating

Experimental Material

 Yorkshire piglets

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-4 (ATF4) has been reported to activate the transcription of SLC38A9 gene in amino acid deprivation condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Breast; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        NFE2L3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A9 gene in colon cancer condition [6]

TF Protein Name

 Nuclear factor erythroid 2-related factor 3 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 BALB/cAJcl-Foxn1nu mice

Detailed Description

 Nuclear factor erythroid 2-related factor 3 (NFE2L3) has been reported to activate the transcription of SLC38A9 gene in colon cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A9 gene in glioblastoma multiforme condition [7]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC38A9 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        TFAP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 Transcription factor AP-4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-4 (TFAP4) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 4 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A9 gene in prostate cancer condition [8]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC38A9 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

       Transcriptional Phenomenon2

 Binding to SLC38A9 gene in . condition [9]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC38A9 gene in . condition, which leads to a affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

       Transcriptional Phenomenon3

 Binding to SLC38A9 gene in prostate cancer condition [10]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC38A9 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

       Transcriptional Phenomenon4

 Activation of SLC38A9 gene in castration-resistant prostate cancers condition [11]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Androgen receptor (AR) has been reported to activate the transcription of SLC38A9 gene in castration-resistant prostate cancers condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A9 gene in health condition [12]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC38A9 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        PGR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Progesterone receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Progesterone receptor (PGR) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A9 gene in multiple sclerosis condition [13]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC38A9 gene in multiple sclerosis condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A9 gene in multiple human cancer types condition [14]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC38A9 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        HOXB13 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 Homeobox protein Hox-B13 Transcription Factor Info

Tissue

 Colon; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Homeobox protein Hox-B13 (HOXB13) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Colon; Embryo; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        ETS1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A9 gene in T cell activation condition [15]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Protein C-ets-1 (ETS1) has been reported to activate the transcription of SLC38A9 gene in T cell activation condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 9.

       Transcriptional Phenomenon2

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

        SPIB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [1]

TF Protein Name

 Transcription factor Spi-B Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Spi-B (SPIB) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [5]

TF Protein Name

 Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [3]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A9 gene [4]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC38A9 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 9.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-409. (ID:ENSG00000177058)
2 Identification of amino acid response element of SLC38A9 as an ATF4-binding site in porcine skeletal muscle cells. Biochem Biophys Res Commun. 2021 Sep 10;569:167-173.
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 NRF3 activates mTORC1 arginine-dependently for cancer cell viability. iScience. 2023 Jan 25;26(2):106045.
7 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
9 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
10 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
11 Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene. 2012;31(17):2153-63.
12 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
13 Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes. Mult Scler. 2013;19(8):1035-45.
14 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
15 DNA specificity determinants associate with distinct transcription factor functions. PLoS Genet. 2009;5(12):e1000778.

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