Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0294 Transporter Info
Gene Name SLC35B3
Transporter Name Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Gene ID
51000
UniProt ID
Q9H1N7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

      Class1.2: Basic helix-loop-helix factors

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        MAX 

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       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [2]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35B3 gene in embryonic stem cells condition [3]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC35B3 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

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        GATA3 

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       Transcriptional Phenomenon1

 Binding to SLC35B3 gene in breast cancer condition [4]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC35B3 gene in breast cancer condition, which leads to an affected expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

      Class2.3: C2H2 zinc finger factors

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        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [5]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        FOXP2 

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       Transcriptional Phenomenon1

 Binding to SLC35B3 gene in health condition [6]

TF Protein Name

 Forkhead box protein P2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC35B3 gene in health condition, which leads to an affected expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

      Class3.5: Tryptophan cluster factors

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        EHF 

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       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [5]

TF Protein Name

 ETS homologous factor Transcription Factor Info

Tissue

 Bronchus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS homologous factor (EHF) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        ERG 

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       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [7]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [1]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35B3 gene in megakaryocytes condition [8]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC35B3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC35B3 gene [7]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35B3 gene in acute myeloid leukemia condition [9]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC35B3 gene in acute myeloid leukemia condition, which leads to an affected expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35B3 gene in megakaryocytes condition [8]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC35B3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC35B3 gene in health condition [10]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC35B3 gene in health condition, which leads to an increased expression of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

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        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35B3 gene [2]

TF Protein Name

 Transcription initiation factor IIB Transcription Factor Info

Tissue

 Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription initiation factor IIB (GTF2B) can directly bind to the SLC35B3 gene, which in turn affects the expression or function of the drug transporter Adenosine 3'-phospho 5'-phosphosulfate transporter 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-253. (ID:ENSG00000124786)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
4 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
7 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
9 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
10 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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