Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0280 Transporter Info
Gene Name SLC31A2
Transporter Name Probable low affinity copper uptake protein 2
Gene ID
1318
UniProt ID
O15432

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [2]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [1]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [3]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC31A2 gene in . condition, which leads to a affected expression of the drug transporter Probable low affinity copper uptake protein 2.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [4]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [3]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC31A2 gene in podocyte condition [6]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC31A2 gene in podocyte condition, which leads to an increased expression of the drug transporter Probable low affinity copper uptake protein 2.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [2]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

      Class3.5: Tryptophan cluster factors

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        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [4]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [2]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [7]

TF Protein Name

 Signal transducer and activator of transcription 1-alpha/beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC31A2 gene in . condition, which leads to an affected expression of the drug transporter Probable low affinity copper uptake protein 2.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC31A2 gene in epithelial to mesenchymal transition condition [8]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC31A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Probable low affinity copper uptake protein 2.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC31A2 gene in megakaryocytes condition [9]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC31A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Probable low affinity copper uptake protein 2.

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [1]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [4]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        NFIA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC31A2 gene in colon cancer condition [10]

TF Protein Name

 Nuclear factor 1 A-type Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Nuclear factor 1 A-type (NFIA) has been reported to activate the transcription of SLC31A2 gene in colon cancer condition, which leads to an increased expression of the drug transporter Probable low affinity copper uptake protein 2.

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC31A2 gene in health condition [11]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC31A2 gene in health condition, which leads to an affected expression of the drug transporter Probable low affinity copper uptake protein 2.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC31A2 gene in epithelial ovarian cancer condition [12]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC31A2 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Probable low affinity copper uptake protein 2.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.5: GTF2I domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2I 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC31A2 gene [2]

TF Protein Name

 General transcription factor II-I Transcription Factor Info

Tissue

 Foreskin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 General transcription factor II-I (GTF2I) can directly bind to the SLC31A2 gene, which in turn affects the expression or function of the drug transporter Probable low affinity copper uptake protein 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-277. (ID:ENSG00000136867)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
6 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
7 MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.
8 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
9 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10 NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G175-81.
11 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.
12 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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