Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0272 Transporter Info | ||||
Gene Name | SLC30A3 | ||||
Transporter Name | Zinc transporter 3 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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ATF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
Cyclic AMP-dependent transcription factor ATF-3 | Transcription Factor Info | ||||
Tissue |
Blood; Colon; Embryo; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
CEBPB |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Tissue |
Blood; Breast; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Embryo; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
JUN |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene in coronary artery disease condition | [4] | ||||
TF Protein Name |
Transcription factor Jun | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC30A3 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
JUNB |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
Transcription factor JunB | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor JunB (JUNB) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
JUND |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene in coronary artery disease condition | [4] | ||||
TF Protein Name |
Transcription factor JunD | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC30A3 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
Class1.2: Basic helix-loop-helix factors |
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BHLHE40 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
Class E basic helix-loop-helix protein 40 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
MAX |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Protein max | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Brain; Breast; Colon; Embryo; Liver; Lung; Uterus; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein max (MAX) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
TCF12 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Transcription factor 12 | Transcription Factor Info | ||||
Tissue |
Blood; Brain; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor 12 (TCF12) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
TCF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
Transcription factor E2-alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2-alpha (TCF3) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
USF2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Upstream stimulatory factor 2 | Transcription Factor Info | ||||
Tissue |
Embryo; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Upstream stimulatory factor 2 (USF2) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class1.3: Basic helix-span-helix factors |
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TFAP2C |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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AR |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene | [6] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Androgen receptor (AR) has been reported to bind to the transcription of SLC30A3 gene in . condition, which leads to a affected expression of the drug transporter Zinc transporter 3. | |||||
NR2F2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
COUP transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
COUP transcription factor 2 (NR2F2) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
PPARD |
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Transcriptional Phenomenon1 |
Repression of SLC30A3 gene in myofibroblasts condition | [7] | ||||
TF Protein Name |
Peroxisome proliferator-activated receptor delta | Transcription Factor Info | ||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC30A3 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Zinc transporter 3. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
GATA4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
Transcription factor GATA-4 | Transcription Factor Info | ||||
Tissue |
Heart | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor GATA-4 (GATA4) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class2.3: C2H2 zinc finger factors |
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CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
EGR1 |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene in erythroleukemia condition | [8] | ||||
TF Protein Name |
Early growth response protein 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC30A3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
SALL4 |
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Transcriptional Phenomenon1 |
Activation of SLC30A3 gene in health condition | [9] | ||||
TF Protein Name |
Sal-like protein 4 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLC30A3 gene in health condition, which leads to an increased expression of the drug transporter Zinc transporter 3. | |||||
SP1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Transcription factor Sp1 | Transcription Factor Info | ||||
Tissue |
Colon; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Sp1 (SP1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
SP4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Transcription factor Sp4 | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Sp4 (SP4) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
YY1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
Transcriptional repressor protein YY1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Brain; Embryo; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Breast; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
E2F6 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Transcription factor E2F6 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F6 (E2F6) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
FOXA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Embryo; Liver; Lung; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
FOXP1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [5] | ||||
TF Protein Name |
Forkhead box protein P1 | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Forkhead box protein P1 (FOXP1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class3.5: Tryptophan cluster factors |
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ELF1 |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene | [6] | ||||
TF Protein Name |
ETS-related transcription factor Elf-1 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC30A3 gene in . condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
ERG |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
Transcriptional regulator ERG | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional regulator ERG (ERG) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
FLI1 |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene in megakaryocytes condition | [10] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC30A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
GABPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [1] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Bone marrow; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
SPI1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class5.1: MADS box factors |
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SRF |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [3] | ||||
TF Protein Name |
Serum response factor | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Serum response factor (SRF) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
Class6.1: Rel homology region factors |
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RBPJ |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene in immortal lymphoblast cell lines (LCLs) condition | [11] | ||||
TF Protein Name |
Recombining binding protein suppressor of hairless | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC30A3 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
Class6.3: p53 domain factors |
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TP53 |
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Transcriptional Phenomenon1 |
Binding to SLC30A3 gene in HFKS condition | [12] | ||||
TF Protein Name |
Cellular tumor antigen p53 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC30A3 gene in HFKS condition, which leads to an affected expression of the drug transporter Zinc transporter 3. | |||||
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold |
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Class7.1: SMAD/NF-1 DNA-binding domain factors |
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NFIC |
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Transcriptional Phenomenon1 |
Direct binding to SLC30A3 gene | [2] | ||||
TF Protein Name |
Nuclear factor 1 C-type | Transcription Factor Info | ||||
Tissue |
Brain; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear factor 1 C-type (NFIC) can directly bind to the SLC30A3 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 3. | |||||
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