Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0263 Transporter Info | ||||
Gene Name | SLC2A5 | ||||
Transporter Name | Glucose transporter type 5, small intestine | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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ATF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
Cyclic AMP-dependent transcription factor ATF-3 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
BACH1 |
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Transcriptional Phenomenon1 |
Activation of SLC2A5 gene in breast cancer bone metastasis condition | [2] | ||||
TF Protein Name |
Transcription regulator protein BACH1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC2A5 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Glucose transporter type 5. | |||||
BACH2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
Transcription regulator protein BACH2 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
CEBPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
CEBPB |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Tissue |
Bone | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
FOS |
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Transcriptional Phenomenon1 |
Activation of SLC2A5 gene in health condition | [6] | ||||
TF Protein Name |
Protein c-Fos | Transcription Factor Info | ||||
Studied Phenotype |
Heallth [ICD11: N.A] | |||||
Tissue |
Brain | |||||
Related DT Changes |
up regulating | |||||
Experimental Material |
Mouse microglia cells (SIM-A9) | |||||
Detailed Description |
Protein c-Fos (FOS), influenced by the exogenous glucose, has been reported to activate the transcription of SLC2A5 gene in health condition , which leads to an increased expression of the drug transporter Glucose transporter type 5. | |||||
Class1.2: Basic helix-loop-helix factors |
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ARNT |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
BHLHE40 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Class E basic helix-loop-helix protein 40 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
MLXIPL |
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Transcriptional Phenomenon1 |
Activation of SLC2A5 gene in health condition | [7] | ||||
TF Protein Name |
Carbohydrate-responsive element-binding protein | Transcription Factor Info | ||||
Studied Phenotype |
Heallth [ICD11: N.A] | |||||
Tissue |
Small intestine | |||||
Related DT Changes |
Up regulating | |||||
Experimental Material |
C57BL/6J mice | |||||
Detailed Description |
Carbohydrate-responsive element-binding protein (MLXIPL) has been reported to activate the transcription of SLC2A5 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 5. | |||||
MYOD1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
Myoblast determination protein 1 | Transcription Factor Info | ||||
Tissue |
Myotube | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myoblast determination protein 1 (MYOD1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
TCF21 |
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Transcriptional Phenomenon1 |
Binding to SLC2A5 gene in Coronary Artery Disease (CAD) condition | [8] | ||||
TF Protein Name |
Transcription factor 21 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor 21 (TCF21) has been reported to bind to the SLC2A5 gene in Coronary Artery Disease (CAD) condition, which affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
USF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
Upstream stimulatory factor 1 | Transcription Factor Info | ||||
Tissue |
Brain; Embryo; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Upstream stimulatory factor 1 (USF1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class1.3: Basic helix-span-helix factors |
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TFAP2A |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
Transcription factor AP-2-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
TFAP2C |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast; Cervix; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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ESR1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
Estrogen receptor | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Estrogen receptor (ESR1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
NR1H3 |
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Transcriptional Phenomenon1 |
Activation of SLC2A5 gene in type 2 diabetes condition | [9] | ||||
TF Protein Name |
Oxysterols receptor LXR-alpha | Transcription Factor Info | ||||
Affected Drug/Substrate |
Fructose | |||||
Studied Phenotype |
Type 2 diabetes [ICD11: 5A11] | |||||
Tissue |
Duodenum | |||||
Related DT Changes |
Up regulating | |||||
Experimental Material |
C57BL/6J mice | |||||
Detailed Description |
Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC2A5 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Glucose transporter type 5. | |||||
NR2F2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
COUP transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
COUP transcription factor 2 (NR2F2) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
RXRG |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Retinoic acid receptor RXR-gamma | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class2.3: C2H2 zinc finger factors |
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CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Striated muscle | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
KLF4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
Krueppel-like factor 4 | Transcription Factor Info | ||||
Tissue |
Foreskin; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 4 (KLF4) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
YY1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
Transcriptional repressor protein YY1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
ZBTB7A |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
Zinc finger and BTB domain-containing protein 7A | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class3.2: Paired box factors |
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PAX5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
Paired box protein Pax-5 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Paired box protein Pax-5 (PAX5) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class3.3: Fork head / winged helix factors |
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FOXA1 |
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Transcriptional Phenomenon1 |
Binding to SLC2A5 gene in prostate cancer condition | [10] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC2A5 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Glucose transporter type 5. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC2A5 gene | [4] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Liver; Lung; Pancreatic ductal; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
FOXA2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-beta | Transcription Factor Info | ||||
Tissue |
Embryo; Liver; Lung; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
Class3.5: Tryptophan cluster factors |
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FLI1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [5] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
GABPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Bone marrow; Liver; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
SPI1 |
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Transcriptional Phenomenon1 |
Binding to SLC2A5 gene in APL condition | [11] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC2A5 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Glucose transporter type 5. | |||||
Class6.1: Rel homology region factors |
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EBF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [3] | ||||
TF Protein Name |
Transcription factor COE1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor COE1 (EBF1) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
RELA |
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Transcriptional Phenomenon1 |
Activation of SLC2A5 gene in fibrosarcoma condition | [12] | ||||
TF Protein Name |
Transcription factor p65 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Transcription factor p65 (RELA) has been reported to activate the transcription of SLC2A5 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 5. | |||||
Class6.2: STAT domain factors |
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STAT1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [13] | ||||
TF Protein Name |
Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC2A5 gene in . condition, which leads to a affected expression of the drug transporter Glucose transporter type 5. | |||||
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold |
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Class7.1: SMAD/NF-1 DNA-binding domain factors |
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NFIC |
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Transcriptional Phenomenon1 |
Direct binding to SLC2A5 gene | [1] | ||||
TF Protein Name |
Nuclear factor 1 C-type | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear factor 1 C-type (NFIC) can directly bind to the SLC2A5 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 5. | |||||
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