Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0257 Transporter Info
Gene Name	SLC2A2
Transporter Name	Glucose transporter type 2, liver
Gene ID	6514
UniProt ID	P11168

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in breast cancer bone metastasis condition			[1]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC2A2 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in hepatoblastoma condition			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) has been reported to activate the transcription of SLC2A2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in hepatoblastoma condition			[2]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) has been reported to activate the transcription of SLC2A2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[3]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Brain; Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[4]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Brain; Colon; Coronary artery; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
MAFB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in diabetes mellitus condition			[5]
TF Protein Name	Transcription factor MafB		Transcription Factor Info
Affected Drug/Substrate	Insulin
Studied Phenotype	Diabetes mellitus [ICD11: 5A10-5A14]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Transcription factor MafB (MAFB) has been reported to activate the transcription of SLC2A2 gene in diabetes mellitus condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
SREBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of GLUT2 gene in insulinoma condition			[6]
TF Protein Name	Sterol regulatory element-binding protein 1		Transcription Factor Info
Studied Phenotype	Insulinoma [ICD11: 2C10.1]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/129OlaHsd mice
Detailed Description	Sterol regulatory element-binding protein 1 (SREBF1) has been reported to activate the transcription of GLUT2 gene in insulinoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A2 gene in glioblastoma multiforme condition			[7]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC2A2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Glucose transporter type 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A2 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC2A2 gene in health condition, which leads to an affected expression of the drug transporter Glucose transporter type 2.
NR1H2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of GLUT2 gene in insulinoma condition			[6]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Studied Phenotype	Insulinoma [ICD11: 2C10.1]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/129OlaHsd mice
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of GLUT2 gene in insulinoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
PPARA		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in hepatoblastoma condition			[9]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	Insulin
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA), influenced by the exogenous oleic Acid, has been reported to activate the transcription of SLC2A2 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter Glucose transporter type 2.
Transcriptional Phenomenon2	Activation of SLC2A2 gene in type 2 diabetes condition			[10]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	Zucker diabetic fatty rat
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC2A2 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[11]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[12]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[3]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
CDX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in health condition			[13]
TF Protein Name	Homeobox protein CDX-2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Related DT Changes	Up regulating
Detailed Description	Homeobox protein CDX-2 (CDX2), influenced by the faecalibacterium prausnitzii, has been reported to activate the transcription of SLC2A2 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in multiple human cancer types condition			[14]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC2A2 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
DUX4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[12]
TF Protein Name	Double homeobox protein 4		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Double homeobox protein 4 (DUX4) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
HNF1A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in type 2 diabetes condition			[15]
TF Protein Name	Hepatocyte nuclear factor 1-alpha		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Embryo
Related DT Changes	Up regulating
Experimental Material	Mouse embryo fibroblast cells (NIH-3T3)
Detailed Description	Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLC2A2 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
HNF1B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in renal cysts condition			[16]
TF Protein Name	Hepatocyte nuclear factor 1-beta		Transcription Factor Info
Studied Phenotype	Renal cysts [ICD11: GB80]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Zebrafish TgPT::EGFP)
Detailed Description	Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC2A2 gene in renal cysts condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
NKX6-1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in diabetes mellitus condition			[17]
TF Protein Name	Homeobox protein Nkx-6.1		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Diabetes mellitus [ICD11: 5A10-5A14]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	129Sv-C57BL6/J hybrid mice
Detailed Description	Homeobox protein Nkx-6.1 (NKX6-1) has been reported to activate the transcription of SLC2A2 gene in diabetes mellitus condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
ONECUT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in hepatoblastoma condition			[18]
TF Protein Name	Hepatocyte nuclear factor 6		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Hepatocyte nuclear factor 6 (ONECUT1) has been reported to activate the transcription of SLC2A2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in ovarian cancer condition			[19]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC2A2 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A2 gene in diabetes mellitus condition			[20]
TF Protein Name	Paired box protein Pax-6		Transcription Factor Info
Affected Drug/Substrate	Insulin
Studied Phenotype	Diabetes mellitus [ICD11: 5A10-5A14]
Tissue	Pancreas
Related DT Changes	Down regulating
Experimental Material	Pax6 KO mice
Detailed Description	Paired box protein Pax-6 (PAX6) has been reported to repress the transcription of SLC2A2 gene in diabetes mellitus condition, which leads to a decreased expression of the drug transporter Glucose transporter type 2.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
FOXA2		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A2 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC2A2 gene in health condition, which leads to an affected expression of the drug transporter Glucose transporter type 2.
Transcriptional Phenomenon2	Activation of SLC2A2 gene in type 2 diabetes condition			[15]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Embryo
Related DT Changes	Up regulating
Experimental Material	Mouse embryo fibroblast cells (NIH-3T3)
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to activate the transcription of SLC2A2 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Transcriptional Phenomenon3	Repression of SLC2A2 gene in insulinoma condition			[21]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Insulinoma [ICD11: 2C10.1]
Tissue	Pancreas
Related DT Changes	Down regulating
Experimental Material	Rat insulinoma cells (INS-1)
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to repress the transcription of SLC2A2 gene in insulinoma condition, which leads to a decreased expression of the drug transporter Glucose transporter type 2.
Transcriptional Phenomenon4	Repression of SLC2A2 gene in hepatoblastoma condition			[18]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to repress the transcription of SLC2A2 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter Glucose transporter type 2.
FOXA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in effects of			[22]
TF Protein Name	Hepatocyte nuclear factor 3-gamma		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Effects of hunger [ICD11: NF07.0]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Hepatocyte nuclear factor 3-gamma (FOXA3) has been reported to activate the transcription of SLC2A2 gene in effects of hunger condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in tumorigenesis condition			[23]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC2A2 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in health condition			[24]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Interferon regulatory factor 1 (IRF1) has been reported to activate the transcription of SLC2A2 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[11]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.
TF Superclass6: Immunoglobulin fold
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A2 gene in obesity condition			[25]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	2-deoxyglucose
Studied Phenotype	Obesity [ICD11: 5B81]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	RIP-Cre-STAT3/loxP hybrid mice
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC2A2 gene in obesity condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Transcriptional Phenomenon2	Activation of SLC2A2 gene in health condition			[26]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	2-deoxyglucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	White Leghorn chicken hepatocyte isolates
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC2A2 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Transcriptional Phenomenon3	Activation of SLC2A2 gene in glioblastoma multiforme condition			[7]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC2A2 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Glucose transporter type 2.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A2 gene in HFKS condition			[27]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC2A2 gene in HFKS condition, which leads to an affected expression of the drug transporter Glucose transporter type 2.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A2 gene in epithelial to mesenchymal transition condition			[28]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC2A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Glucose transporter type 2.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A2 gene			[4]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC2A2 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 2.

References
1	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2	CCAAT/enhancer binding protein regulates the promoter activity of the rat GLUT2 glucose transporter gene in liver cells. Biochem J. 1998 Nov 15;336 ( Pt 1)(Pt 1):83-90.
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-360. (ID:ENSG00000163581)
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	MafB Maintains beta-Cell Identity under MafA-Deficient Conditions. Mol Cell Biol. 2022 Aug 18;42(8):e0054121.
6	Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Endocrinology. 2006 Aug;147(8):3898-905.
7	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9	Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model. J Zhejiang Univ Sci B. 2013 Feb;14(2):115-23.
10	Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11921-6.
11	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
12	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
13	Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011;6(9):e24585.
14	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
15	Identification of transacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene. Cooperative role of hepatocyte nuclear factors 1alpha and 3beta. J Biol Chem. 2000 Jun 16;275(24):18358-65.
16	Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
17	Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 2013 Sep 26;4(6):1262-75.
18	Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol Cell Biol. 2003 Jan;23(2):437-49.
19	Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
20	The transcription factor Pax6 is required for pancreatic beta cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice. J Biol Chem. 2017 May 26;292(21):8892-8906.
21	Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J Biol Chem. 2002 May 17;277(20):17564-70.
22	Foxa3 (hepatocyte nuclear factor 3gamma ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. J Biol Chem. 2001 Nov 16;276(46):42812-7.
23	Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
24	A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response. Nucleic Acids Res. 2009;37(4):1073-85.
25	Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.
26	Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. J Cell Physiol. 2009 Mar;218(3):643-52.
27	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
28	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.

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Detail Information of Transcriptional Regulations

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