General Information of Drug Transporter (DT)
DT ID DTD0253 Transporter Info
Gene Name SLC2A11
Transporter Name Glucose transporter type 11
Gene ID
66035
UniProt ID
Q9BYW1

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        CEBPB 

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       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

Blood; Bone marrow; Breast; Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        FOS 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Protein c-Fos Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Protein c-Fos (FOS) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        MAFK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Transcription factor MafK Transcription Factor Info

Tissue

Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor MafK (MAFK) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Aryl hydrocarbon receptor Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Aryl hydrocarbon receptor (AHR) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Protein max Transcription Factor Info

Tissue

Blood; Bone marrow; Breast; Embryo; Liver; Lung; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Protein max (MAX) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        MNT 

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       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Max-binding protein MNT Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Max-binding protein MNT (MNT) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Myoblast determination protein 1 Transcription Factor Info

Tissue

Myotube

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myoblast determination protein 1 (MYOD1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        TCF12 

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       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Transcription factor 12 Transcription Factor Info

Tissue

Blood; Embryo; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor 12 (TCF12) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Transcription factor E2-alpha Transcription Factor Info

Tissue

Blood; Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2-alpha (TCF3) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        TFAP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Transcription factor AP-4 Transcription Factor Info

Tissue

Blood; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-4 (TFAP4) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Transcription factor AP-2-alpha Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Transcription factor AP-2 gamma Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

COUP transcription factor 2 Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

COUP transcription factor 2 (NR2F2) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Erythroid transcription factor Transcription Factor Info

Tissue

Blood; Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Erythroid transcription factor (GATA1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 12 TF(s) Regulating This DT

        BCL11A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

B-cell lymphoma/leukemia 11A Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

B-cell lymphoma/leukemia 11A (BCL11A) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Transcriptional repressor CTCF Transcription Factor Info

Tissue

Brain

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional repressor CTCF (CTCF) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        CTCFL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Transcriptional repressor CTCFL Transcription Factor Info

Tissue

Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Early growth response protein 1 Transcription Factor Info

Tissue

Blood; Bone marrow; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Early growth response protein 1 (EGR1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Krueppel-like factor 4 Transcription Factor Info

Tissue

Foreskin; Pancreatic ductal

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 4 (KLF4) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Krueppel-like factor 5 Transcription Factor Info

Tissue

Colon; Pancreatic ductal; Stomach

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 5 (KLF5) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 9 (KLF9) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Myc-associated zinc finger protein Transcription Factor Info

Tissue

Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myc-associated zinc finger protein (MAZ) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        SP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Transcription factor Sp1 Transcription Factor Info

Tissue

Blood; Colon; Embryo; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor Sp1 (SP1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        SP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Transcription factor Sp4 Transcription Factor Info

Tissue

Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor Sp4 (SP4) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

Bone marrow; Liver; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Zinc finger protein 263 Transcription Factor Info

Tissue

Bone marrow; Kidney

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger protein 263 (ZNF263) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        POU2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

POU domain, class 2, transcription factor 1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class3.3: Fork head / winged helix factors

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        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Transcription factor E2F1 Transcription Factor Info

Tissue

Blood; Breast; Cervix

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F1 (E2F1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Transcription factor E2F6 Transcription Factor Info

Tissue

Bone marrow; Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F6 (E2F6) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC2A11 gene in prostate cancer condition [5]

TF Protein Name

Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC2A11 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Glucose transporter type 11.

        FOXP1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Repression of SLC2A11 gene in embryonic stem cell condition [6]

TF Protein Name

Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Down regulating

Detailed Description

Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC2A11 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Glucose transporter type 11.

       Transcriptional Phenomenon2

Direct binding to SLC2A11 gene [3]

TF Protein Name

Forkhead box protein P1 Transcription Factor Info

Tissue

Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Forkhead box protein P1 (FOXP1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Transcriptional regulator ERG Transcription Factor Info

Tissue

Aorta

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional regulator ERG (ERG) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Protein C-ets-1 Transcription Factor Info

Tissue

Blood; Bone; Bone marrow; Kidney; Vein

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Protein C-ets-1 (ETS1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC2A11 gene in megakaryocytes condition [7]

TF Protein Name

Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

Direct regulating

Detailed Description

Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC2A11 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Glucose transporter type 11.

       Transcriptional Phenomenon2

Direct binding to SLC2A11 gene [2]

TF Protein Name

Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

Blood; Mesenchymal; Vein

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

GA-binding protein alpha chain Transcription Factor Info

Tissue

Liver; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

GA-binding protein alpha chain (GABPA) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Transcription factor PU.1 Transcription Factor Info

Tissue

Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor PU.1 (SPI1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class3.7: ARID domain factors

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        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Lysine-specific demethylase 5B Transcription Factor Info

Tissue

Bone marrow; Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [3]

TF Protein Name

Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SRF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Serum response factor Transcription Factor Info

Tissue

Embryo; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Serum response factor (SRF) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Transcription factor COE1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor COE1 (EBF1) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class6.3: p53 domain factors

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        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC2A11 gene in health condition [8]

TF Protein Name

Tumor protein 63 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC2A11 gene in health condition, which leads to an affected expression of the drug transporter Glucose transporter type 11.

      Class6.4: Runt domain factors

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        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

Runt-related transcription factor 3 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

      Class6.7: Grainyhead domain factors

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        GRHL2 

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       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [1]

TF Protein Name

Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

Breast; Bronchus; Ovary

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        NFIC 

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       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [4]

TF Protein Name

Nuclear factor 1 C-type Transcription Factor Info

Tissue

Brain

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Nuclear factor 1 C-type (NFIC) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.

TF Superclass8: beta-Sheet binding to DNA

      Class8.1: TATA-binding proteins

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        TBP 

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       Transcriptional Phenomenon1

Direct binding to SLC2A11 gene [2]

TF Protein Name

TATA-box-binding protein Transcription Factor Info

Tissue

Bone marrow; Embryo; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

TATA-box-binding protein (TBP) can directly bind to the SLC2A11 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 11.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-269. (ID:ENSG00000133460)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
6 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
7 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
8 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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