Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0250 Transporter Info
Gene Name SLC29A4
Transporter Name Equilibrative nucleoside transporter 4
Gene ID
222962
UniProt ID
Q7RTT9

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        TCF3 

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       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [1]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

      Class1.3: Basic helix-span-helix factors

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        TFAP2C 

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       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [2]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC29A4 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC29A4 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 4.

        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC29A4 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC29A4 gene in health condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 4.

        NR2F2 

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       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [5]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

      Class2.3: C2H2 zinc finger factors

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        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC29A4 gene in erythroleukemia condition [6]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC29A4 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 4.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [1]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [7]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

        WT1 

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       Transcriptional Phenomenon1

 Activation of SLC29A4 gene in desmoplastic small round cell tumor condition [8]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Affected Drug/Substrate

 Adenosine

Studied Phenotype

 Desmoplastic small round cell tumor [ICD11: 2B5K]

Tissue

 Abdomen

Related DT Changes

 Up regulating

Experimental Material

 Human childhood desmoplastic small round cell tumor cells (JN-DSRCT-1)

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC29A4 gene in desmoplastic small round cell tumor condition, which leads to an increased expression of the drug transporter Equilibrative nucleoside transporter 4.

        ZBTB7A 

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       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [2]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

        ZNF263 

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       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [7]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Colon; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [2]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        FOXP2 

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       Transcriptional Phenomenon1

 Binding to SLC29A4 gene in health condition [9]

TF Protein Name

 Forkhead box protein P2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC29A4 gene in health condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 4.

      Class3.5: Tryptophan cluster factors

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        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [5]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [2]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

      Class3.7: ARID domain factors

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        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [7]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.

TF Superclass6: Immunoglobulin fold

      Class6.7: Grainyhead domain factors

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        GRHL3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC29A4 gene [1]

TF Protein Name

 Grainyhead-like protein 3 homolog Transcription Factor Info

Tissue

 Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the SLC29A4 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 4.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-367. (ID:ENSG00000164638)
3 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
4 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
7 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8 Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor. PLoS One. 2008 Jun 4;3(6):e2353.
9 Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.

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