Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0243 Transporter Info
Gene Name SLC27A6
Transporter Name Long-chain fatty acid transport protein 6
Gene ID
28965
UniProt ID
Q9Y2P4

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC27A6 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC27A6 gene, which in turn affects the expression or function of the drug transporter Long-chain fatty acid transport protein 6.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        SREBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A6 gene in health condition [2]

TF Protein Name

 Sterol regulatory element-binding protein 1 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 goat mammary epithelial cell isolates

Detailed Description

 Sterol regulatory element-binding protein 1 (SREBF1) has been reported to activate the transcription of SLC27A6 gene in health condition, which leads to an increased expression of the drug transporter Long-chain fatty acid transport protein 6.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A6 gene in glioblastoma multiforme condition [3]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC27A6 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Long-chain fatty acid transport protein 6.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC27A6 gene [4]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC27A6 gene, which in turn affects the expression or function of the drug transporter Long-chain fatty acid transport protein 6.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A6 gene in podocyte condition [5]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC27A6 gene in podocyte condition, which leads to an increased expression of the drug transporter Long-chain fatty acid transport protein 6.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ELK1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC27A6 gene in . condition [6]

TF Protein Name

 ETS domain-containing protein Elk-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of SLC27A6 gene in . condition, which leads to an affected expression or function of the drug transporter Long-chain fatty acid transport protein 6.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC27A6 gene [7]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC27A6 gene, which in turn affects the expression or function of the drug transporter Long-chain fatty acid transport protein 6.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC27A6 gene [8]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC27A6 gene, which in turn affects the expression or function of the drug transporter Long-chain fatty acid transport protein 6.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC27A6 gene in megakaryocytes condition [9]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC27A6 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Long-chain fatty acid transport protein 6.

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A6 gene in prostate cancer condition [10]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC27A6 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Long-chain fatty acid transport protein 6.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-221. (ID:ENSG00000113396)
2 Rapid communication: lipid metabolic gene expression and triacylglycerol accumulation in goat mammary epithelial cells are decreased by inhibition of SREBP-1. J Anim Sci. 2018 Jun 4;96(6):2399-2407.
3 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
6 ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8(5):e1002694.
7 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
8 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
9 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.