Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0233 Transporter Info
Gene Name SLC26A5
Transporter Name Prestin
Gene ID
375611
UniProt ID
P58743

Transcriptional Regulation of This DT (TSR)

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in prostate cancer condition [1]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC26A5 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Prestin.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC26A5 gene in health condition, which leads to an affected expression of the drug transporter Prestin.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in megakaryocytes condition [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC26A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Prestin.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A5 gene in hematopoiesis condition [4]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC26A5 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Prestin.

      Class2.3: C2H2 zinc finger factors

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        IKZF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A5 gene in sensorineural hearing loss condition [5]

TF Protein Name

 Zinc finger protein Helios Transcription Factor Info

Studied Phenotype

 Sensorineural hearing loss [ICD11: AB50]

Tissue

 Cello cochlear

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6N mice

Detailed Description

 Zinc finger protein Helios (IKZF2) has been reported to activate the transcription of SLC26A5 gene in sensorineural hearing loss condition, which leads to an increased expression of the drug transporter Prestin.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in prostate carcinoma condition [6]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC26A5 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Prestin.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC26A5 gene in health condition, which leads to an affected expression of the drug transporter Prestin.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A5 gene [7]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC26A5 gene, which in turn affects the expression or function of the drug transporter Prestin.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in megakaryocytes condition [3]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC26A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Prestin.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A5 gene in HaCaT keratinocytes condition [8]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC26A5 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Prestin.
References
1 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
2 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
3 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
4 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
5 Helios is a key transcriptional regulator of outer hair cell maturation. Nature. 2018 Nov;563(7733):696-700.
6 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
7 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-395. (ID:ENSG00000170615)
8 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.

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