Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0199 Transporter Info
Gene Name	SLC25A37
Transporter Name	Mitochondrial iron transporter 1
Gene ID	51312
UniProt ID	Q9NYZ2

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ATF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-1		Transcription Factor Info
Tissue	Bone marrow; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in breast cancer bone metastasis condition			[3]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC25A37 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in melanoma condition			[6]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC25A37 gene in melanoma condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Embryo; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in glioblastoma multiforme condition			[7]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC25A37 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in prostate cancer condition			[8]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC25A37 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Androgen receptor		Transcription Factor Info
Tissue	Breast; Cervix; Kidney; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Androgen receptor (AR) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in health condition			[9]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A37 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in hematopoiesis condition			[10]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC25A37 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
Transcriptional Phenomenon2	Binding to SLC25A37 gene in megakaryocytes condition			[11]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC25A37 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in hematopoiesis condition			[10]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC25A37 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 13 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in health condition			[12]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC25A37 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in erythroleukemia condition			[13]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC25A37 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
SALL4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in health condition			[14]
TF Protein Name	Sal-like protein 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLC25A37 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in podocyte condition			[15]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC25A37 gene in podocyte condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
HOXA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Homeobox protein Hox-A6		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Hox-A6 (HOXA6) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
POU2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	POU domain, class 2, transcription factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
SIX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Homeobox protein SIX5		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein SIX5 (SIX5) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in tumorigenesis condition			[16]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC25A37 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ELK3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in hypoxia condition			[17]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC25A37 gene in hypoxia condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC25A37 gene			[1]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A37 gene in megakaryocytes condition			[11]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC25A37 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial iron transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[5]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow; Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[1]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A37 gene in fibrosarcoma condition			[18]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of SLC25A37 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Mitochondrial iron transporter 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[4]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 2 (RUNX2) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A37 gene			[2]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC25A37 gene, which in turn affects the expression or function of the drug transporter Mitochondrial iron transporter 1.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-320. (ID:ENSG00000147454)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
7	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
9	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
11	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
12	The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
13	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
14	SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
15	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
16	Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
17	The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
18	Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.

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