Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0193 Transporter Info
Gene Name SLC25A31
Transporter Name Adenine nucleotide translocator 4
Gene ID
83447
UniProt ID
Q9H0C2

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        MYC 

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       Transcriptional Phenomenon1

 Direct binding to SLC25A31 gene [1]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) can directly bind to the SLC25A31 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 4.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F6 

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       Transcriptional Phenomenon1

 Repression of SLC25A31 gene in health condition [2]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Embryo

Related DT Changes

 Down regulating

Experimental Material

 Mouse embryo embryonic stem cells (ES-R1)

Detailed Description

 Transcription factor E2F6 (E2F6) has been reported to repress the transcription of SLC25A31 gene in health condition, which leads to a decreased expression of the drug transporter Adenine nucleotide translocator 4.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC25A31 gene in health condition [3]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC25A31 gene in health condition, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 4.

      Class6.4: Runt domain factors

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        RUNX2 

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       Transcriptional Phenomenon1

 Activation of SLC25A31 gene in prostate cancer condition [4]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC25A31 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 4.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC25A31 gene in epithelial ovarian cancer condition [5]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC25A31 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 4.
References
1 Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008;36(21):e144.
2 A conserved E2F6-binding element in murine meiosis-specific gene promoters. Biol Reprod. 2008 Nov;79(5):921-30.
3 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
4 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
5 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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