Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0176 Transporter Info
Gene Name SLC25A17
Transporter Name Peroxisomal membrane protein PMP34
Gene ID
10478
UniProt ID
O43808

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        BACH2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 Transcription regulator protein BACH2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A17 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC25A17 gene in breast cancer condition, which leads to an increased expression of the drug transporter Peroxisomal membrane protein PMP34.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A17 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC25A17 gene in breast cancer condition, which leads to an increased expression of the drug transporter Peroxisomal membrane protein PMP34.

        CLOCK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A17 gene in cancer condition [5]

TF Protein Name

 Circadian locomoter output cycles protein kaput Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Circadian locomoter output cycles protein kaput (CLOCK) has been reported to activate the transcription of SLC25A17 gene in cancer condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

        HEY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Hairy/enhancer-of-split related with YRPW motif protein 1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A17 gene in melanoma condition [7]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC25A17 gene in melanoma condition, which leads to an increased expression of the drug transporter Peroxisomal membrane protein PMP34.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in embryonic stem cells condition [8]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC25A17 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Embryo; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 1 (USF1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in prostate cancer condition [9]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC25A17 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in health condition [10]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A17 gene in health condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in health condition [11]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC25A17 gene in health condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        POU2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 POU domain, class 2, transcription factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        E2F7 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 Transcription factor E2F7 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F7 (E2F7) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Blood; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        TFDP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Transcription factor Dp-1 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Dp-1 (TFDP1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene [12]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC25A17 gene in . condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

        ELF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 ETS-related transcription factor Elf-2 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS-related transcription factor Elf-2 (ELF2) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in oncogenesis condition [12]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional regulator ERG (ERG) has been reported to bind to the transcription of SLC25A17 gene in oncogenesis condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        SPI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in HL60 condition [12]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC25A17 gene in HL60 condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

       Transcriptional Phenomenon2

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

 Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

        NFYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [6]

TF Protein Name

 Nuclear transcription factor Y subunit beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A17 gene in health condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC25A17 gene in health condition, which leads to an affected expression of the drug transporter Peroxisomal membrane protein PMP34.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [1]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [2]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.

TF Superclass8: beta-Sheet binding to DNA

      Class8.1: TATA-binding proteins

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TBP 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A17 gene [3]

TF Protein Name

 TATA-box-binding protein Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 TATA-box-binding protein (TBP) can directly bind to the SLC25A17 gene, which in turn affects the expression or function of the drug transporter Peroxisomal membrane protein PMP34.
References
1 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-182. (ID:ENSG00000100372)
4 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
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