Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0142 Transporter Info
Gene Name SLC22A16
Transporter Name Fly-like putative transporter 2
Gene ID
85413
UniProt ID
Q86VW1

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        ASCL1 

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       Transcriptional Phenomenon1

 Direct binding to SLC22A16 gene [1]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC22A16 gene, which in turn affects the expression or function of the drug transporter Fly-like putative transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        PPARD 

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       Transcriptional Phenomenon1

 Repression of SLC22A16 gene in myofibroblasts condition [2]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC22A16 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Fly-like putative transporter 2.

        VDR 

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       Transcriptional Phenomenon1

 Direct binding to SLC22A16 gene in human monocytic leukemia condition [3]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the SLC22A16 gene in human monocytic leukemia condition, which affects the expression or function of the drug transporter Fly-like putative transporter 2.

      Class2.3: C2H2 zinc finger factors

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        WT1 

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       Transcriptional Phenomenon1

 Activation of SLC22A16 gene in podocyte condition [4]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC22A16 gene in podocyte condition, which leads to an increased expression of the drug transporter Fly-like putative transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

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        FLI1 

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       Transcriptional Phenomenon1

 Binding to SLC22A16 gene in megakaryocytes condition [5]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC22A16 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Fly-like putative transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

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       Transcriptional Phenomenon1

 Binding to SLC22A16 gene in glioblastoma multiforme condition [6]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC22A16 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Fly-like putative transporter 2.

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC22A16 gene in epithelial to mesenchymal transition condition [7]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC22A16 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Fly-like putative transporter 2.

       Transcriptional Phenomenon2

 Binding to SLC22A16 gene in health condition [8]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC22A16 gene in health condition, which leads to an affected expression of the drug transporter Fly-like putative transporter 2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD3 

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       Transcriptional Phenomenon1

 Activation of SLC22A16 gene in hESCs condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC22A16 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Fly-like putative transporter 2.

        SMAD4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC22A16 gene in health condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC22A16 gene in health condition, which leads to an increased expression of the drug transporter Fly-like putative transporter 2.

       Transcriptional Phenomenon2

 Binding to SLC22A16 gene in epithelial ovarian cancer condition [10]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC22A16 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Fly-like putative transporter 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-129. (ID:ENSG00000004809)
2 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
3 Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
4 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
5 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
8 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
9 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.
10 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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