Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0124 Transporter Info
Gene Name SLC18A3
Transporter Name Vesicular acetylcholine transporter
Gene ID
6572
UniProt ID
Q16572

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC18A3 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC18A3 gene, which in turn affects the expression or function of the drug transporter Vesicular acetylcholine transporter.

        JUND 

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       Transcriptional Phenomenon1

 Binding to SLC18A3 gene in coronary artery disease condition [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC18A3 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Vesicular acetylcholine transporter.

      Class1.2: Basic helix-loop-helix factors

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        HAND2 

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       Transcriptional Phenomenon1

 Repression of SLC18A3 gene in health condition [3]

TF Protein Name

 Heart- and neural crest derivatives-expressed protein 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Nerve

Related DT Changes

 Down regulating

Experimental Material

 Chick

Detailed Description

 Heart- and neural crest derivatives-expressed protein 2 (HAND2) has been reported to repress the transcription of SLC18A3 gene in health condition, which leads to a decreased expression of the drug transporter Vesicular acetylcholine transporter.

        MYC 

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       Transcriptional Phenomenon1

 Repression of SLC18A3 gene in medulloblastoma condition [4]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC18A3 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Vesicular acetylcholine transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        AR 

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       Transcriptional Phenomenon1

 Binding to SLC18A3 gene in prostate cancer condition [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC18A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Vesicular acetylcholine transporter.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC18A3 gene in erythroleukemia condition [6]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC18A3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Vesicular acetylcholine transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SATB2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A3 gene in health condition [7]

TF Protein Name

 DNA-binding protein SATB2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Nerve

Related DT Changes

 Up regulating

Experimental Material

 Rat superior cervical ganglia isolates

Detailed Description

 DNA-binding protein SATB2 (SATB2) has been reported to activate the transcription of SLC18A3 gene in health condition, which leads to an increased expression of the drug transporter Vesicular acetylcholine transporter.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A3 gene in alzheimer disease condition [8]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Studied Phenotype

 Alzheimer disease [ICD11: 8A20]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 CD-1 mice

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC18A3 gene in alzheimer disease condition, which leads to an increased expression of the drug transporter Vesicular acetylcholine transporter.

      Class6.3: p53 domain factors

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        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC18A3 gene in health condition [9]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC18A3 gene in health condition, which leads to an affected expression of the drug transporter Vesicular acetylcholine transporter.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-434. (ID:ENSG00000187714)
2 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3 The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons. Dev Biol. 2009 May 15;329(2):191-200.
4 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
5 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
6 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
7 The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2. J Neurosci. 2010 Dec 1;30(48):16356-64.
8 Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology. 2008 Jul;33(8):2020-32.
9 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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