Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0101 Transporter Info
Gene Name SLC16A10
Transporter Name Monocarboxylate transporter 10
Gene ID
117247
UniProt ID
Q8TF71

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A10 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC16A10 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 10.

        MAFF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A10 gene [2]

TF Protein Name

 Transcription factor MafF Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor MafF (MAFF) can directly bind to the SLC16A10 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 10.

        MAFK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A10 gene [3]

TF Protein Name

 Transcription factor MafK Transcription Factor Info

Tissue

 Bone marrow; Cervix; Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor MafK (MAFK) can directly bind to the SLC16A10 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 10.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A10 gene in melanoma condition [4]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC16A10 gene in melanoma condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 10.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in health condition [5]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC16A10 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in megakaryocytes condition [6]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC16A10 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

      Class2.3: C2H2 zinc finger factors

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        BCL6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A10 gene in health condition [7]

TF Protein Name

 B-cell lymphoma 6 protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC16A10 gene in health condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 10.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A10 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A10 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 10.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in melanocyte deficiency condition [8]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional repressor protein YY1 (YY1) has been reported to bind to the transcription of SLC16A10 gene in melanocyte deficiency condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A10 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC16A10 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 10.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SIX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A10 gene in health condition [9]

TF Protein Name

 Homeobox protein SIX1 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Skeletal muscle

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Homeobox protein SIX1 (SIX1) has been reported to activate the transcription of SLC16A10 gene in health condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 10.

      Class3.3: Fork head / winged helix factors

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        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene [5]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC16A10 gene in . condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC16A10 gene in embryonic stem cell condition [10]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC16A10 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 10.

      Class3.5: Tryptophan cluster factors

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        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene [11]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC16A10 gene in . condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A10 gene [12]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC16A10 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 10.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A10 gene in colorectal cancer condition [13]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC16A10 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 10.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in immortal lymphoblast cell lines (LCLs) condition [14]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC16A10 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

      Class6.3: p53 domain factors

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        TP53 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in HFKS condition [15]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC16A10 gene in HFKS condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

       Transcriptional Phenomenon2

 Binding to SLC16A10 gene in tumorigenesis condition [16]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC16A10 gene in tumorigenesis condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in epithelial to mesenchymal transition condition [17]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC16A10 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A10 gene in epithelial ovarian cancer condition [18]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC16A10 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 10.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-216. (ID:ENSG00000112394)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
5 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
6 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
7 The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
8 YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.
9 Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter. Skelet Muscle. 2021 Nov 19;11(1):26.
10 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
11 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
12 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
13 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
14 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
15 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
16 A global map of p53 transcription-factor binding sites in the human genome. Cell. 2006;124(1):207-19.
17 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
18 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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