Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0079 Transporter Info
Gene Name SLC10A7
Transporter Name Sodium/bile acid cotransporter 7
Gene ID
84068
UniProt ID
Q0GE19

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to SLC10A7 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC10A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC10A7 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC10A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

       Transcriptional Phenomenon2

 Direct binding to SLC10A7 gene [4]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC10A7 gene in . condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

        VDR 

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       Transcriptional Phenomenon1

 Binding to SLC10A7 gene in health condition [5]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC10A7 gene in health condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [6]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A7 gene in gastric cancer condition [7]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC10A7 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium/bile acid cotransporter 7.

      Class2.3: C2H2 zinc finger factors

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        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [1]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [8]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

        WT1 

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       Transcriptional Phenomenon1

 Activation of SLC10A7 gene in podocyte condition [9]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC10A7 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium/bile acid cotransporter 7.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        FOXA1 

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       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [10]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [6]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

      Class3.5: Tryptophan cluster factors

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        FLI1 

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       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [8]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene [10]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC10A7 gene, which in turn affects the expression or function of the drug transporter Sodium/bile acid cotransporter 7.

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A7 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC10A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

      Class6.3: p53 domain factors

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        TP53 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC10A7 gene in HFKS condition [11]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC10A7 gene in HFKS condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

       Transcriptional Phenomenon2

 Binding to SLC10A7 gene in stress response condition [12]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC10A7 gene in stress response condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A7 gene in epithelial to mesenchymal transition condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC10A7 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC10A7 gene in epithelial ovarian cancer condition [14]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC10A7 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium/bile acid cotransporter 7.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-243. (ID:ENSG00000120519)
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
4 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
5 Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
6 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
7 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
8 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
9 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
10 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
11 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
12 Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
13 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
14 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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