Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0064 Transporter Info
Gene Name ABCD2
Transporter Name Adrenoleukodystrophy-like 1
Gene ID
225
UniProt ID
Q9UBJ2

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in breast cancer condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of ABCD2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SREBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in health condition [2]

TF Protein Name

 Sterol regulatory element-binding protein 1 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 129S2/SvPas mice

Detailed Description

 Sterol regulatory element-binding protein 1 (SREBF1) has been reported to activate the transcription of ABCD2 gene in health condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCD2 gene in MCF7 cells [3]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of ABCD2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Adrenoleukodystrophy-like 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        NR1H2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of ABCD2 gene in health condition [4]

TF Protein Name

 Oxysterols receptor LXR-beta Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Oxysterols receptor LXR-beta (NR1H2) has been reported to repress the transcription of ABCD2 gene in health condition, which leads to a decreased expression of the drug transporter Adrenoleukodystrophy-like 1.

        NR1H3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of ABCD2 gene in health condition [4]

TF Protein Name

 Oxysterols receptor LXR-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Oxysterols receptor LXR-alpha (NR1H3) has been reported to repress the transcription of ABCD2 gene in health condition, which leads to a decreased expression of the drug transporter Adrenoleukodystrophy-like 1.

        PPARA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in x-linked adrenoleukodystrophy condition [5]

TF Protein Name

 Peroxisome proliferator-activated receptor alpha Transcription Factor Info

Studied Phenotype

 X-linked adrenoleukodystrophy [ICD11: 5C57.1]

Tissue

 Adrenal gland

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of ABCD2 gene in x-linked adrenoleukodystrophy condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in health condition [6]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of ABCD2 gene in health condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

        THRB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in health condition [7]

TF Protein Name

 Thyroid hormone receptor beta Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Thyroid hormone receptor beta (THRB) has been reported to activate the transcription of ABCD2 gene in health condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

        VDR 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in health condition [8]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of ABCD2 gene in health condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

       Transcriptional Phenomenon2

 Binding to ABCD2 gene in health condition [9]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of ABCD2 gene in health condition, which leads to an affected expression of the drug transporter Adrenoleukodystrophy-like 1.

       Transcriptional Phenomenon3

 Binding to ABCD2 gene in THP-1 human monocytic leukemia cells condition [10]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of ABCD2 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter Adrenoleukodystrophy-like 1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in podocyte condition [11]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of ABCD2 gene in podocyte condition, which leads to an increased expression of the drug transporter Adrenoleukodystrophy-like 1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCD2 gene in multiple human cancer types condition [12]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of ABCD2 gene in multiple human cancer types condition, which leads to an affected expression of the drug transporter Adrenoleukodystrophy-like 1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCD2 gene in MCF7 cells [3]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of ABCD2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Adrenoleukodystrophy-like 1.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCD2 gene in glioblastoma multiforme condition [13]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of ABCD2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Adrenoleukodystrophy-like 1.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Distinct modulatory roles for thyroid hormone receptors TRalpha and TRbeta in SREBP1-activated ABCD2 expression. Eur J Cell Biol. 2008 Dec;87(12):933-45.
3 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
4 Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation. J Biol Chem. 2005 Dec 16;280(50):41243-51.
5 Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy. Mol Genet Metab. 2003 Dec;80(4):398-407.
6 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
7 Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2). Mol Pharmacol. 2003 Jun;63(6):1296-303.
8 A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 2010;20(10):1352-60.
9 Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
10 Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
11 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
12 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
13 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.

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