Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0051 Transporter Info
Gene Name ABCB5
Transporter Name ATP-binding cassette sub-family B member 5
Gene ID
340273
UniProt ID
Q2M3G0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of ABCB5 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of ABCB5 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family B member 5.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB5 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCB5 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family B member 5.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB5 gene in K562 cells [3]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of ABCB5 gene in K562 cells, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in melanoma condition [4]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 Melanoma [ICD11: 2C30]

Tissue

 Skin

Related DT Changes

 Up regulating

Experimental Material

 human melanoma cell isolates

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of ABCB5 gene in melanoma condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

        mutated MITF (p.E318K) 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in renal cell cancer condition [5]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 Renal cell cancer [ICD11: 2C90]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Human clear cell renal cell carcinoma cells (RCC4)

Detailed Description

 mutated Microphthalmia-associated transcription factor (mutated MITF (p.E318K)) has been reported to activate the transcription of ABCB5 gene in renal cell cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

        MYC 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in colon cancer condition [6]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Affected Drug/Substrate

 5-fluorouracil

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 human colon cancer cell isolates

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to activate the transcription of ABCB5 gene in colon cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

       Transcriptional Phenomenon2

 Direct binding to ABCB5 gene in HL60 condition [7]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of ABCB5 gene in HL60 condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB5 gene in glioblastoma multiforme condition [8]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of ABCB5 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB5 gene in prostate cancer condition [9]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of ABCB5 gene in prostate cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

       Transcriptional Phenomenon2

 Binding to ABCB5 gene in prostate cancer condition [10]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of ABCB5 gene in prostate cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB5 gene in health condition [11]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCB5 gene in health condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of ABCB5 gene in myofibroblast condition [12]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of ABCB5 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family B member 5.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in health condition [13]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to activate the transcription of ABCB5 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

       Transcriptional Phenomenon2

 Binding to ABCB5 gene in megakaryocytes condition [14]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of ABCB5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB5 gene [15]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the ABCB5 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family B member 5.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in breast cancer condition [16]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 human breast cancer cell isolates

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) has been reported to activate the transcription of ABCB5 gene in breast cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB5 gene in megakaryocytes condition [14]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of ABCB5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in glioblastoma multiforme condition [8]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of ABCB5 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP73 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in breast cancer condition [17]

TF Protein Name

 Tumor protein p73 Transcription Factor Info

Affected Drug/Substrate

 Adriamycin

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 Human invasive breast carcinoma of no special type cells (MCF-7)

Detailed Description

 Tumor protein p73 (TP73) has been reported to activate the transcription of ABCB5 gene in breast cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB5 gene in prostate cancer condition [18]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ABCB5 gene in prostate cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB5 gene in epithelial ovarian cancer condition [19]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of ABCB5 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family B member 5.

       Transcriptional Phenomenon2

 Activation of ABCB5 gene in hESCs condition [20]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of ABCB5 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family B member 5.
References
1 In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-130. (ID:ENSG00000004846)
3 c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
4 ABCB5 is activated by MITF and beta-catenin and is associated with melanoma differentiation. Pigment Cell Melanoma Res. 2020 Jan;33(1):112-118.
5 A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature. 2011 Oct 19;480(7375):94-8.
6 The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells. J Cell Mol Med. 2015 Jul;19(7):1569-81.
7 Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008;36(21):e144.
8 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
9 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
10 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
11 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
12 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
13 Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol. 2012;32(1):226-39.
14 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
15 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
16 ABCB5-ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells. Oncol Res. 2017 Mar 13;25(3):305-316.
17 deltaNp73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report. Cell Oncol (Dordr). 2017 Dec;40(6):631-638.
18 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
19 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.
20 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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