Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0030 Transporter Info
Gene Name SLCO1B3
Transporter Name Organic anion transporting polypeptide 1B3
Gene ID
28234
UniProt ID
Q9NPD5

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLCO1B3 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NR1H4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in hepatoblastoma condition [2]

TF Protein Name

 Bile acid receptor Transcription Factor Info

Studied Phenotype

 Hepatoblastoma [ICD11: 2C12.01]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human hepatoblastoma cells (HepG2)

Detailed Description

 Bile acid receptor (NR1H4) has been reported to activate the transcription of SLCO1B3 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

       Transcriptional Phenomenon2

 Activation of SLCO1B3 gene in hepatocellular carcinoma condition [3]

TF Protein Name

 Bile acid receptor Transcription Factor Info

Studied Phenotype

 Hepatocellular carcinoma [ICD11: 2C12.02]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human childhood hepatocellular carcinoma cells (Hep3B)

Detailed Description

 Bile acid receptor (NR1H4) has been reported to activate the transcription of SLCO1B3 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

        NR1I2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in health condition [4]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Related DT Changes

 Up regulating

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the metabolite from Host unspecified microbiota, has been reported to activate the transcription of SLCO1B3 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in gastric cancer condition [5]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLCO1B3 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in gastric cancer condition [5]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLCO1B3 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in hepatocellular carcinoma condition [3]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Hepatocellular carcinoma [ICD11: 2C12.02]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human childhood hepatocellular carcinoma cells (Hep3B)

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLCO1B3 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B3 gene in hepatocellular carcinoma condition [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Studied Phenotype

 Hepatocellular carcinoma [ICD11: 2C12.02]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human childhood hepatocellular carcinoma cells (Hep3B)

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to activate the transcription of SLCO1B3 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B3.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1B3 gene in glioblastoma multiforme condition [6]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLCO1B3 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1B3.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology. 2002 Jun;122(7):1954-66.
3 Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. J Gastroenterol. 2006 Apr;41(4):369-77.
4 Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther. 2022 Sep;237:108238.
5 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.

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