Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0021 Transporter Info
Gene Name SLC15A1
Transporter Name Peptide transporter 1
Gene ID
6564
UniProt ID
P46059

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC15A1 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in colon cancer condition [2]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco2-BBE)

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) has been reported to activate the transcription of SLC15A1 gene in colon cancer condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

        NFE2L2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in colon cancer condition [3]

TF Protein Name

 Nuclear factor erythroid 2-related factor 2 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous resveratrol, has been reported to activate the transcription of SLC15A1 gene in colon cancer condition , which leads to an increased expression of the drug transporter Peptide transporter 1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in melanoma condition [4]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC15A1 gene in melanoma condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC15A1 gene in prostate cancer condition [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC15A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Peptide transporter 1.

        PPARA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in effects of [6]

TF Protein Name

 Peroxisome proliferator-activated receptor alpha Transcription Factor Info

Affected Drug/Substrate

 Glycylsarcosine

Studied Phenotype

 Effects of hunger [ICD11: NF07.0]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Wistar rats

Detailed Description

 Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC15A1 gene in effects of hunger condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in tumorigenic prostate condition [7]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to activate the transcription of SLC15A1 gene in tumorigenic prostate condition, which leads to an affected expression of the drug transporter Peptide transporter 1.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in gastric cancer condition [8]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Affected Drug/Substrate

 Metformin

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC15A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        CDX2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in gastric cancer condition [9]

TF Protein Name

 Homeobox protein CDX-2 Transcription Factor Info

Studied Phenotype

 Gastric cancer [ICD11: 2B72]

Tissue

 Stomach

Related DT Changes

 Up regulating

Experimental Material

 human gastric cancer cell isolates

Detailed Description

 Homeobox protein CDX-2 (CDX2) has been reported to activate the transcription of SLC15A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

       Transcriptional Phenomenon2

 Activation of SLC15A1 gene in colitis condition [10]

TF Protein Name

 Homeobox protein CDX-2 Transcription Factor Info

Studied Phenotype

 Colitis [ICD11: 1A40]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 FVB mice

Detailed Description

 Homeobox protein CDX-2 (CDX2) has been reported to activate the transcription of SLC15A1 gene in colitis condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in HESC condition [11]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC15A1 gene in HESC condition, which leads to an increased expression of the drug transporter Peptide transporter 1.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC15A1 gene in stress response condition [12]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC15A1 gene in stress response condition, which leads to an affected expression of the drug transporter Peptide transporter 1.

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC15A1 gene in epithelial to mesenchymal transition condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC15A1 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Peptide transporter 1.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC15A1 gene in prostate cancer condition [14]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC15A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Peptide transporter 1.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors. J Biol Chem. 2007 Jan 12;282(2):1359-73.
3 Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2. Biochim Biophys Acta. 2014 Jun;1840(6):1747-54.
4 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
5 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
6 Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G851-6.
7 Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol. 2008;9(11):R166.
8 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
9 The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1. Biochem Pharmacol. 2006 May 28;71(11):1581-8.
10 Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response. Gastroenterology. 2009 Oct;137(4):1435-47.e1-2.
11 Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
12 Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
13 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
14 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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