Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0015 Transporter Info
Gene Name	ABCC4
Transporter Name	Multidrug resistance-associated protein 4
Gene ID	10257
UniProt ID	O15439

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
NFE2L2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in health condition			[3]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of ABCC4 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in breast cancer condition			[4]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of ABCC4 gene in breast cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon2	Activation of ABCC4 gene in hepatoblastoma condition			[5]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Aryl hydrocarbon receptor (AHR), influenced by the exogenous polychlorinated dibenzodioxin, has been reported to activate the transcription of ABCC4 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon3	Activation of ABCC4 gene in lung adenocarcinoma condition			[6]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Lung adenocarcinoma [ICD11: 2C25.0]
Tissue	Lung
Related DT Changes	up regulating
Experimental Material	Human lung adenocarcinoma cells (H358)
Detailed Description	Aryl hydrocarbon receptor (AHR), influenced by the exogenous polychlorinated dibenzodioxin, has been reported to activate the transcription of ABCC4 gene in lung adenocarcinoma condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in breast cancer condition			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of ABCC4 gene in breast cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in melanoma condition			[7]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of ABCC4 gene in melanoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[8]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[9]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in MCF7 cells			[10]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of ABCC4 gene in MCF7 cells, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in prostate cancer condition			[11]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ABCC4 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon2	Binding to ABCC4 gene in prostate cancer condition			[12]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ABCC4 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon3	Activation of ABCC4 gene in castration-resistant prostate cancers condition			[13]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of ABCC4 gene in castration-resistant prostate cancers condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in health condition			[14]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCC4 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
NR1H4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC4 gene in cholestasis condition			[15]
TF Protein Name	Bile acid receptor		Transcription Factor Info
Studied Phenotype	Cholestasis [ICD11: DC10.02]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	CD-1 mice
Detailed Description	Bile acid receptor (NR1H4) has been reported to repress the transcription of ABCC4 gene in cholestasis condition, which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 4.
NR1I2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in health condition			[16]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Related DT Changes	Up regulating
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the metabolite from Host unspecified microbiota, has been reported to activate the transcription of ABCC4 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
NR1I3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in health condition			[3]
TF Protein Name	Nuclear receptor subfamily 1 group I member 3		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear receptor subfamily 1 group I member 3 (NR1I3) has been reported to activate the transcription of ABCC4 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in hematopoiesis condition			[17]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of ABCC4 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon2	Binding to ABCC4 gene in megakaryocytes condition			[18]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of ABCC4 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon3	Direct binding to ABCC4 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
GATA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in hematopoiesis condition			[17]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of ABCC4 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon2	Direct binding to ABCC4 gene			[2]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood; Bone marrow; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in gastric cancer condition			[19]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of ABCC4 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[9]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in erythroleukemia condition			[20]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of ABCC4 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[8]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in multiple human cancer types condition			[21]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of ABCC4 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in health condition			[22]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of ABCC4 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Cervix; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[8]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in health condition			[14]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ABCC4 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in breast cancer condition			[23]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of ABCC4 gene in breast cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in tumorigenesis condition			[24]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of ABCC4 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[2]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[9]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[1]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in K562 cells condition			[25]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of ABCC4 gene in K562 cells condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Transcriptional Phenomenon2	Direct binding to ABCC4 gene			[8]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in health condition			[26]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCC4 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC4 gene in megakaryocytes condition			[18]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of ABCC4 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 4.
Class6.5: T-Box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EOMES		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in health condition			[27]
TF Protein Name	Eomesodermin homolog		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Eomesodermin homolog (EOMES) has been reported to activate the transcription of ABCC4 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC4 gene			[1]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Blood; Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the ABCC4 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 4.
TF Superclass10: Yet undefined DNA-binding domains
Class10: Uncharacterized		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC4 gene in health condition			[28]
TF Protein Name	Nuclear respiratory factor 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Bone
Related DT Changes	up regulating
Experimental Material	mouse bone marrow-derived mesenchymal stem cells
Detailed Description	Nuclear respiratory factor 1 (NRF1), influenced by the exogenous arsenic, has been reported to activate the transcription of ABCC4 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 4.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-254. (ID:ENSG00000125257)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos. 2005 Jul;33(7):956-62.
4	High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
5	Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G126-35.
6	Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells. Toxicol Lett. 2012 Feb 25;209(1):58-66.
7	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
8	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
9	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
10	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
11	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
12	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
13	Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene. 2012;31(17):2153-63.
14	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
15	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. PLoS One. 2012;7(1):e30443.
16	Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther. 2022 Sep;237:108238.
17	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
18	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
19	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
20	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
21	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
22	Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
23	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
24	Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
25	Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
26	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
27	Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25(3):238-50.
28	Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux. Toxicol Appl Pharmacol. 2020 Nov 15;407:115251.

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Detail Information of Transcriptional Regulations

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