Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0202 Transporter Info
Gene Name	SLC25A4
Transporter Name	Adenine nucleotide translocator 1
Gene ID	291
UniProt ID	P12235

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ATF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-2		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A4 gene in melanoma condition			[3]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC25A4 gene in melanoma condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 1.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[2]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
MYC		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene in HL60 condition			[4]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC25A4 gene in HL60 condition, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 1.
Transcriptional Phenomenon2	Repression of SLC25A4 gene in medulloblastoma condition			[5]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC25A4 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Adenine nucleotide translocator 1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[6]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[6]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[7]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[7]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A4 gene			[8]
TF Protein Name	Androgen receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC25A4 gene in . condition, which leads to a affected expression of the drug transporter Adenine nucleotide translocator 1.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[2]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A4 gene in myofibroblast condition			[9]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of SLC25A4 gene in myofibroblast condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 1.
RXRA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[1]
TF Protein Name	Retinoic acid receptor RXR-alpha		Transcription Factor Info
Tissue	Blood; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-alpha (RXRA) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A4 gene in multiple sclerosis condition			[10]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC25A4 gene in multiple sclerosis condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A4 gene in hematopoiesis condition			[11]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC25A4 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[6]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A4 gene in erythroleukemia condition			[12]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC25A4 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[7]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
REST		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A4 gene in glioblastoma condition			[13]
TF Protein Name	RE1-silencing transcription factor		Transcription Factor Info
Studied Phenotype	Glioblastoma [ICD11: 2A00.00]
Tissue	Brain
Related DT Changes	Down regulating
Experimental Material	Human glioblastoma cells (U-87)
Detailed Description	RE1-silencing transcription factor (REST) has been reported to repress the transcription of SLC25A4 gene in glioblastoma condition, which leads to a decreased expression of the drug transporter Adenine nucleotide translocator 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[6]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[6]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[1]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Embryo; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[6]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[7]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[7]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A4 gene in colorectal cancer condition			[14]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC25A4 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 1.
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[1]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
NFYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[2]
TF Protein Name	Nuclear transcription factor Y subunit beta		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFKB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A4 gene in glioblastoma condition			[15]
TF Protein Name	Nuclear factor NF-kappa-B p105 subunit		Transcription Factor Info
Studied Phenotype	Glioblastoma [ICD11: 2A00.00]
Tissue	Brain
Related DT Changes	Down regulating
Experimental Material	Human glioblastoma cells (T98G)
Detailed Description	Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to repress the transcription of SLC25A4 gene in glioblastoma condition, which leads to a decreased expression of the drug transporter Adenine nucleotide translocator 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A4 gene			[1]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC25A4 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 1.
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A4 gene in epithelial ovarian cancer condition			[16]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC25A4 gene in epithelial ovarian cancer condition, which leads to an increased expression of the drug transporter Adenine nucleotide translocator 1.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-329. (ID:ENSG00000151729)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
4	Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008;36(21):e144.
5	Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
6	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
7	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
9	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
10	Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes. Mult Scler. 2013;19(8):1035-45.
11	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
12	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
13	Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells. Int J Mol Sci. 2016 May 3;17(5):664.
14	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
15	Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017 Mar 20;7:44708.
16	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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Detail Information of Transcriptional Regulations

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