Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0100 Transporter Info
Gene Name SLC16A1
Transporter Name Monocarboxylate transporter 1
Gene ID
6566
UniProt ID
P53985

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ATF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-1 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        JUNB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 Transcription factor JunB Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunB (JUNB) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        CLOCK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in colorectal cancer condition [5]

TF Protein Name

 Circadian locomoter output cycles protein kaput Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Circadian locomoter output cycles protein kaput (CLOCK) has been reported to activate the transcription of SLC16A1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in melanoma condition [6]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC16A1 gene in melanoma condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in glioblastoma multiforme condition [7]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC16A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of MCT1 gene in colon cancer condition [8]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Down regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Upstream stimulatory factor 1 (USF1) has been reported to repress the transcription of MCT1 gene in colon cancer condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 1.

        USF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of MCT1 gene in colon cancer condition [8]

TF Protein Name

 Upstream stimulatory factor 2 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Down regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Upstream stimulatory factor 2 (USF2) has been reported to repress the transcription of MCT1 gene in colon cancer condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 1.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in colon cancer condition [9]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to activate the transcription of SLC16A1 gene in colon cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Cervix; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in prostate cancer condition [10]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC16A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in health condition [11]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC16A1 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        PGR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Progesterone receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Progesterone receptor (PGR) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        PPARA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in hepatocellular carcinoma condition [12]

TF Protein Name

 Peroxisome proliferator-activated receptor alpha Transcription Factor Info

Studied Phenotype

 Hepatocellular carcinoma [ICD11: 2C12.02]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC16A1 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in megakaryocytes condition [13]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC16A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

       Transcriptional Phenomenon2

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 9 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in erythroleukemia condition [14]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC16A1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        KLF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Krueppel-like factor 3 Transcription Factor Info

Tissue

 Blood; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 3 (KLF3) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in podocyte condition [15]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC16A1 gene in podocyte condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in multiple human cancer types condition [16]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC16A1 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

        NKX2-1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Homeobox protein Nkx-2.1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PAX6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in diabetes mellitus condition [17]

TF Protein Name

 Paired box protein Pax-6 Transcription Factor Info

Affected Drug/Substrate

 Insulin

Studied Phenotype

 Diabetes mellitus [ICD11: 5A10-5A14]

Tissue

 Pancreas

Related DT Changes

 Up regulating

Experimental Material

 Pax6 KO mice

Detailed Description

 Paired box protein Pax-6 (PAX6) has been reported to activate the transcription of SLC16A1 gene in diabetes mellitus condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in health condition [18]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC16A1 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        E2F8 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Transcription factor E2F8 Transcription Factor Info

Tissue

 Cervix; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F8 (E2F8) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        FOXP2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in health condition [19]

TF Protein Name

 Forkhead box protein P2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC16A1 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ELK3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in hypoxia condition [20]

TF Protein Name

 ETS domain-containing protein Elk-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC16A1 gene in hypoxia condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        NFYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [4]

TF Protein Name

 Nuclear transcription factor Y subunit beta Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        NFKB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in health condition [21]

TF Protein Name

 Nuclear factor NF-kappa-B p105 subunit Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Related DT Changes

 Up regulating

Detailed Description

 Nuclear factor NF-kappa-B p105 subunit (NFKB1), influenced by the dietary food metabolite from Host unspecified microbiota, has been reported to activate the transcription of SLC16A1 gene in health condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A1 gene in fibrosarcoma condition [22]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to activate the transcription of SLC16A1 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 1.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [2]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [3]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in HaCaT keratinocytes condition [23]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC16A1 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A1 gene in health condition [24]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC16A1 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 1.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A1 gene [1]

TF Protein Name

 Transcription initiation factor IIB Transcription Factor Info

Tissue

 Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription initiation factor IIB (GTF2B) can directly bind to the SLC16A1 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 1.
References
1 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-339. (ID:ENSG00000155380)
4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5 Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res. 2010;8(7):952-60.
6 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
7 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8 Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1118-26.
9 PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G275-83.
10 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
11 Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol. 2009;9:68.
12 Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim Biophys Acta. 2008 Jun;1780(6):899-904.
13 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
14 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
15 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
16 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
17 The transcription factor Pax6 is required for pancreatic beta cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice. J Biol Chem. 2017 May 26;292(21):8892-8906.
18 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
19 Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
20 The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
21 Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: involvement of NF-kappaB pathway. J Cell Biochem. 2008 Apr 1;103(5):1452-63.
22 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
23 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.
24 Promoter-wide analysis of Smad4 binding sites in human epithelial cells. Cancer Sci. 2009;100(11):2133-42.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.