Microbe Species Information | VARIDT

General Information of This Microbe species
Species ID	MIC00005
Species Name	Bacillus anthracis
Taxonomy ID	1392
Lineage	Kingdom:Bacteria Phylum:Bacillota Class:Bacilli Order:Bacillales Family:Bacillaceae Genus: Bacillus Species: Bacillus anthracis

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
CACNA1A	Transporter Info	Health [ICD11: N.A]			[1], [2], [3], [4], [5]
FLVCR1	Transporter Info	Health [ICD11: N.A]			[1], [6], [7], [8], [9]
NRAMP2	Transporter Info	Health [ICD11: N.A]			[5], [10], [11], [12], [13]
SLC48A1	Transporter Info	Health [ICD11: N.A]			[1], [6], [7], [8], [9]
SLC49A2	Transporter Info	Health [ICD11: N.A]			[1], [6], [7], [8], [9]
ZIP14	Transporter Info	Health [ICD11: N.A]			[1], [2], [3], [4], [5]
ZIP8	Transporter Info	Health [ICD11: N.A]			[1], [2], [3], [4], [5]

References
1	Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
2	IlsA, a unique surface protein of Bacillus cereus required for iron acquisition from heme, hemoglobin and ferritin. PLoS Pathog. 2009 Nov;5(11):e1000675.
3	Siderophores of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis. Biochem Biophys Res Commun. 2006 Sep 15;348(1):320-5.
4	Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Front Cell Infect Microbiol. 2013 Dec 5;3:90.
5	Iron and manganese transport in mammalian systems. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118890.
6	Heme transfer to the bacterial cell envelope occurs via a secreted hemophore in the Gram-positive pathogen Bacillus anthracis. J Biol Chem. 2009 Nov 13;284(46):32138-46.
7	Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin. PLoS Pathog. 2008 Aug 22;4(8):e1000132.
8	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
9	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
10	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
11	Manganese transport and the role of manganese in virulence. Annu Rev Microbiol. 2006;60:187-209.
12	The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant. Mol Microbiol. 2005 Oct;58(2):533-51.
13	A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3449-54.

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