Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0367 Transporter Info
Gene Name	SLC44A5
Transporter Name	Choline transporter-like protein 5
Gene ID	204962
UniProt ID	Q8NCS7

Post-Translational Modification of This DT
Overview ofSLC44A5 Modification Sites with Functional and Structural Information
Sequence	M N D T E K P A D T P S E E E D F G D P R T Y D P D F K G P V A N R S C T D V L C C M I F L L C I I G Y I V L G L V A W V H G D P R R A A Y P T D S Q G H F C G Q K G T P N E N K T I L F Y F N L L R C T S P S V L L N L Q C P T T Q I C V S K C P E K F L T Y V E M Q L L Y T K D K S Y W E D Y R Q F C K T T A K P V K S L T Q L L L D D D C P T A I F P S K P F L Q R C F P D F S T K N G T L T I G S K M M F Q D G N G G T R S V V E L G I A A N G I N K L L D A K S L G L K V F E D Y A R T W Y W I L I G L T I A M V L S W I F L I L L R F I A G C L F W V F M I G V I G I I G Y G I W H C Y Q Q Y T N L Q E R P S S V L T I Y D I G I Q T N I S M Y F E L Q Q T W F T F M I I L C I I E V I V I L M L I F L R N R I R V A I I L L K E G S K A I G Y V P S T L V Y P A L T F I L L S I C I C Y W V V T A V F L A T S G V P V Y K V I A P G G H C I H E N Q T C D P E I F N T T E I A K A C P G A L C N F A F Y G G K S L Y H Q Y I P T F H V Y N L F V F L W L I N F V I A L G Q C A L A G A F A T Y Y W A M K K P D D I P R Y P L F T A F G R A I R Y H T G S L A F G S L I I A L I Q M F K I V L E Y L D H R L K R T Q N T L S K F L Q C C L R C C F W C L E N A I K F L N R N A Y I M I A I Y G R N F C R S A K D A F N L L M R N V L K V A V T D E V T Y F V L F L G K L L V A G S I G V L A F L F F T Q R L P V I A Q G P A S L N Y Y W V P L L T V I F G S Y L I A H G F F S V Y A M C V E T I F I C F C E D L E R N D G S T E K P Y F V T P N L H G I L I K K Q L V P Q K Q K E
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	88
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC44A5 Asparagine 88 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC44A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	190
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC44A5 Asparagine 190 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC44A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	314
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC44A5 Asparagine 314 has the potential to affect its expression or activity.
Phosphorylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A5			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Serine 12 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A5			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 10 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC44A5			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	127
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 127 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC44A5			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	194
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 194 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 513 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 513 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 513 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Threonine 513 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A5			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Tyrosine 128 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Tyrosine 511 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Tyrosine 511 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Tyrosine 511 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A5 Tyrosine 511 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: CTL5_HUMAN)
2	Quantitative phosphoproteomics analysis reveals a key role of insulin growth factor 1 receptor (IGF1R) tyrosine kinase in human sperm capacitation. Mol Cell Proteomics. 2015 Apr;14(4):1104-12.
3	Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Cancer Res. 2012 May 15;72(10):2501-11.
4	A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples. J Proteome Res. 2012 Nov 2;11(11):5311-22.
5	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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