Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0546 Transporter Info
Gene Name	KCNK9
Transporter Name	Potassium channel subfamily K member 9
Gene ID	51305
UniProt ID	Q9NPC2

Post-Translational Modification of This DT
Overview ofKCNK9 Modification Sites with Functional and Structural Information
Sequence	M K R Q N V R T L S L I V C T F T Y L L V G A A V F D A L E S D H E M R E E E K L K A E E I R I K G K Y N I S S E D Y R Q L E L V I L Q S E P H R A G V Q W K F A G S F Y F A I T V I T T I G Y G H A A P G T D A G K A F C M F Y A V L G I P L T L V M F Q S L G E R M N T F V R Y L L K R I K K C C G M R N T D V S M E N M V T V G F F S C M G T L C I G A A A F S Q C E E W S F F H A Y Y Y C F I T L T T I G F G D Y V A L Q T K G A L Q K K P L Y V A F S F M Y I L V G L T V I G A F L N L V V L R F L T M N S E D E R R D A E E R A S L A G N R N S M V I H I P E E P R P S R P R Y K A D V P D L Q S V C S C T C Y R S Q D Y G G R S V A P Q N S F S A K L A P H Y F H S I S Y K I E E I S P S T L K N S L F P S P I S S I S P G L H S F T D H Q R L M K R R K S V
PTM type	X-Acetylation X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNK9			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	144
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at KCNK9 Lysine 144 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNK9			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	53
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at KCNK9 Asparagine 53 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNK9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	127
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 127 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNK9			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	317
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 317 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 373 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 373 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 373 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 373 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Serine 373 has the potential to affect its expression or activity.
Threonine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNK9			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Threonine 121 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNK9			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	134
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Threonine 134 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	341
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Threonine 341 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	341
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Threonine 341 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	341
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Threonine 341 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNK9			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	113
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Tyrosine 113 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNK9			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	138
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNK9 Tyrosine 138 has the potential to affect its expression or activity.

References
1	Effect of ethinyl estradiol and triton WR 1339 on bile formation and sulfobromophthalein transport maximum (BSPTm) in the rat. Pharmacol Res Commun. 1981 Nov;13(10):903-8.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: KCNK9_HUMAN)
3	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
4	A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples. J Proteome Res. 2012 Nov 2;11(11):5311-22.
5	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
6	Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology. 2018 Jul 3;15(1):44.

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Detail Information of Post-Translational Modifications

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