Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0519 Transporter Info
Gene Name	CACNA1B
Transporter Name	Voltage-gated calcium channel alpha Cav2.2
Gene ID	774
UniProt ID	Q00975

Post-Translational Modification of This DT
Overview ofCACNA1B Modification Sites with Functional and Structural Information
Sequence	M V R F G D E L G G R Y G G P G G G E R A R G G G A G G A G G P G P G G L Q P G Q R V L Y K Q S I A Q R A R T M A L Y N P I P V K Q N C F T V N R S L F V F S E D N V V R K Y A K R I T E W P P F E Y M I L A T I I A N C I V L A L E Q H L P D G D K T P M S E R L D D T E P Y F I G I F C F E A G I K I I A L G F V F H K G S Y L R N G W N V M D F V V V L T G I L A T A G T D F D L R T L R A V R V L R P L K L V S G I P S L Q V V L K S I M K A M V P L L Q I G L L L F F A I L M F A I I G L E F Y M G K F H K A C F P N S T D A E P V G D F P C G K E A P A R L C E G D T E C R E Y W P G P N F G I T N F D N I L F A I L T V F Q C I T M E G W T D I L Y N T N D A A G N T W N W L Y F I P L I I I G S F F M L N L V L G V L S G E F A K E R E R V E N R R A F L K L R R Q Q Q I E R E L N G Y L E W I F K A E E V M L A E E D R N A E E K S P L D V L K R A A T K K S R N D L I H A E E G E D R F A D L C A V G S P F A R A S L K S G K T E S S S Y F R R K E K M F R F F I R R M V K A Q S F Y W V V L C V V A L N T L C V A M V H Y N Q P R R L T T T L Y F A E F V F L G L F L T E M S L K M Y G L G P R S Y F R S S F N C F D F G V I V G S V F E V V W A A I K P G S S F G I S V L R A L R L L R I F K V T K Y W S S L R N L V V S L L N S M K S I I S L L F L L F L F I V V F A L L G M Q L F G G Q F N F Q D E T P T T N F D T F P A A I L T V F Q I L T G E D W N A V M Y H G I E S Q G G V S K G M F S S F Y F I V L T L F G N Y T L L N V F L A I A V D N L A N A Q E L T K D E E E M E E A A N Q K L A L Q K A K E V A E V S P M S A A N I S I A A R Q Q N S A K A R S V W E Q R A S Q L R L Q N L R A S C E A L Y S E M D P E E R L R F A T T R H L R P D M K T H L D R P L V V E L G R D G A R G P V G G K A R P E A A E A P E G V D P P R R H H R H R D K D K T P A A G D Q D R A E A P K A E S G E P G A R E E R P R P H R S H S K E A A G P P E A R S E R G R G P G P E G G R R H H R R G S P E E A A E R E P R R H R A H R H Q D P S K E C A G A K G E R R A R H R G G P R A G P R E A E S G E E P A R R H R A R H K A Q P A H E A V E K E T T E K E A T E K E A E I V E A D K E K E L R N H Q P R E P H C D L E T S G T V T V G P M H T L P S T C L Q K V E E Q P E D A D N Q R N V T R M G S Q P P D P N T I V H I P V M L T G P L G E A T V V P S G N V D L E S Q A E G K K E V E A D D V M R S G P R P I V P Y S S M F C L S P T N L L R R F C H Y I V T M R Y F E V V I L V V I A L S S I A L A A E D P V R T D S P R N N A L K Y L D Y I F T G V F T F E M V I K M I D L G L L L H P G A Y F R D L W N I L D F I V V S G A L V A F A F S G S K G K D I N T I K S L R V L R V L R P L K T I K R L P K L K A V F D C V V N S L K N V L N I L I V Y M L F M F I F A V I A V Q L F K G K F F Y C T D E S K E L E R D C R G Q Y L D Y E K E E V E A Q P R Q W K K Y D F H Y D N V L W A L L T L F T V S T G E G W P M V L K H S V D A T Y E E Q G P S P G Y R M E L S I F Y V V Y F V V F P F F F V N I F V A L I I I T F Q E Q G D K V M S E C S L E K N E R A C I D F A I S A K P L T R Y M P Q N R Q S F Q Y K T W T F V V S P P F E Y F I M A M I A L N T V V L M M K F Y D A P Y E Y E L M L K C L N I V F T S M F S M E C V L K I I A F G V L N Y F R D A W N V F D F V T V L G S I T D I L V T E I A E T N N F I N L S F L R L F R A A R L I K L L R Q G Y T I R I L L W T F V Q S F K A L P Y V C L L I A M L F F I Y A I I G M Q V F G N I A L D D D T S I N R H N N F R T F L Q A L M L L F R S A T G E A W H E I M L S C L S N Q A C D E Q A N A T E C G S D F A Y F Y F V S F I F L C S F L M L N L F V A V I M D N F E Y L T R D S S I L G P H H L D E F I R V W A E Y D P A A C G R I S Y N D M F E M L K H M S P P L G L G K K C P A R V A Y K R L V R M N M P I S N E D M T V H F T S T L M A L I R T A L E I K L A P A G T K Q H Q C D A E L R K E I S V V W A N L P Q K T L D L L V P P H K P D E M T V G K V Y A A L M I F D F Y K Q N K T T R D Q M Q Q A P G G L S Q M G P V S L F H P L K A T L E Q T Q P A V L R G A R V F L R Q K S S T S L S N G G A I Q N Q E S G I K E S V S W G T Q R T Q D A P H E A R P P L E R G H S T E I P V G R S G A L A V D V Q M Q S I T R R G P D G E P Q P G L E S Q G R A A S M P R L A A E T Q P V T D A S P M K R S I S T L A Q R P R G T H L C S T T P D R P P P S Q A S S H H H H H R C H R R R D R K Q R S L E K G P S L S A D M D G A P S S A V G P G L P P G E G P T G C R R E R E R R Q E R G R S Q E R R Q P S S S S S E K Q R F Y S C D R F G G R E P P K P K P S L S S H P T S P T A G Q E P G P H P Q G S G S V N G S P L L S T S G A S T P G R G G R R Q L P Q T P L T P R P S I T Y K T A N S S P I H F A G A Q T S L P A F S P G R L S R G L S E H N A L L Q R D P L S Q P L A P G S R I G S D P Y L G Q R L D S E A S V H A L P E D T L T F E E A V A T N S G R S S R T S Y V S S L T S Q S H P L R R V P N G Y H C T L G L S S G G R A R H S Y H H P D Q D H W C
PTM type	X-Methylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Methylation
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1B Arginine 22 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	256
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1B Asparagine 256 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1563
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1B Asparagine 1563 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1B			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1675
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1B Asparagine 1675 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	68
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at CACNA1B Cystine 68 has the potential to affect its expression or activity.
Phosphorylation
Serine	34 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	411
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 411 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 455 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1B			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	460
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 460 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1B			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	745
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 745 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1B			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	748
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 748 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1B			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	753
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 753 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1B			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	761
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 761 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1B			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	766
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 766 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence CACNA1B			[4], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	783
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 783 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence CACNA1B			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	876
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 876 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence CACNA1B			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	923
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 923 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1069
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1069 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence CACNA1B			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1134
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1134 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence CACNA1B			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1783
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1783 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence CACNA1B			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1793
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1793 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence CACNA1B			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1916
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1916 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence CACNA1B			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1917
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1917 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence CACNA1B			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1919
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1919 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence CACNA1B			[10], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1960
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1960 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence CACNA1B			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1968
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 1968 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence CACNA1B			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2001
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2001 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence CACNA1B			[10], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2016
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2016 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence CACNA1B			[18], [20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2023
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2023 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence CACNA1B			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2129
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2129 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence CACNA1B			[10], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2208
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2208 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence CACNA1B			[10], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2209
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2209 has the potential to affect its expression or activity.
PTM Phenomenon27	Have the potential to influence CACNA1B			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2219
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2219 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence CACNA1B			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2224
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2224 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence CACNA1B			[10], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2233
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2233 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence CACNA1B			[10], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2256
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2256 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence CACNA1B			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2266
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2266 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence CACNA1B			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2295
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2295 has the potential to affect its expression or activity.
PTM Phenomenon33	Have the potential to influence CACNA1B			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2298
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2298 has the potential to affect its expression or activity.
PTM Phenomenon34	Have the potential to influence CACNA1B			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2299
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Serine 2299 has the potential to affect its expression or activity.
Threonine	17 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 176 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 181 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1B			[22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	421
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 421 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1B			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1085
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1085 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1B			[13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1136
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1136 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1B			[18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1584
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1584 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1B			[15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1788
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1788 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1B			[15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1792
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1792 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence CACNA1B			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1794
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1794 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence CACNA1B			[16], [18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1918
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1918 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence CACNA1B			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1961
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 1961 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence CACNA1B			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2024
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 2024 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence CACNA1B			[24]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2193
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 2193 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence CACNA1B			[10], [19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2205
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 2205 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence CACNA1B			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2218
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 2218 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence CACNA1B			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2294
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 2294 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence CACNA1B			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2301
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Threonine 2301 has the potential to affect its expression or activity.
Tyrosine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Tyrosine 463 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[25]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1493
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Tyrosine 1493 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1B			[26]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1736
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Tyrosine 1736 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1B			[27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	2128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Tyrosine 2128 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1B			[27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	2259
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Tyrosine 2259 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1B			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	2296
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B Tyrosine 2296 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[28]
Role of PTM	Potential impacts
Related Enzyme	Protein kinase C alpha type (PRKCA) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1B has the potential to affect its expression or activity.
Ubiquitination
Alanine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	1336
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Alanine 1336 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	1768
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Alanine 1768 has the potential to affect its expression or activity.
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	1769
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Arginine 1769 has the potential to affect its expression or activity.
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1766
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Cystine 1766 has the potential to affect its expression or activity.
Glutamicacid	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1330
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Glutamicacid 1330 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[31]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1332
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Glutamicacid 1332 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1335
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Glutamicacid 1335 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	1763
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Glycine 1763 has the potential to affect its expression or activity.
Isoleucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	1247
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Isoleucine 1247 has the potential to affect its expression or activity.
Leucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1253
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Leucine 1253 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1762
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Leucine 1762 has the potential to affect its expression or activity.
Lysine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	201
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 201 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	374
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 374 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	374
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 374 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	374
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 374 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1B			[19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	417
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 417 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1248
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 1248 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1B			[29], [31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1331
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 1331 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1B			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 1447 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1764
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 1764 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1765
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Lysine 1765 has the potential to affect its expression or activity.
Proline	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[31]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1448
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Proline 1448 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1767
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Proline 1767 has the potential to affect its expression or activity.
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[31]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1249
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Serine 1249 has the potential to affect its expression or activity.
Valine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1B			[29]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	1252
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Valine 1252 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1B			[30]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	1770
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1B Valine 1770 has the potential to affect its expression or activity.

References
1	BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. Nucleic Acids Res. 2018;46(D1):D1128-D1136.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: CAC1B_HUMAN)
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov;14(11):1166-72.
5	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48.
6	Fast Global Phosphoproteome Profiling of Jurkat T Cells by HIFU-TiO2-SCX-LC-MS/MS. Anal Chem. 2017 Sep 5;89(17):8853-8862.
7	Phosphoproteomic and Functional Analyses Reveal Sperm-specific Protein Changes Downstream of Kappa Opioid Receptor in Human Spermatozoa. Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S118-S131.
8	Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome. Proteomics. 2015 Jan;15(2-3):500-7.
9	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
10	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
11	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
12	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
13	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
14	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
15	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
16	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
17	Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6.
18	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
19	Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. Mol Cell. 2020 Mar 5;77(5):1124-1142.e10.
20	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
21	Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins. Proteomics. 2015 Jan;15(2-3):508-519.
22	Cross-talk between G-protein and protein kinase C modulation of N-type calcium channels is dependent on the G-protein beta subunit isoform. J Biol Chem. 2000 Dec 29;275(52):40777-81.
23	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46.
24	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
25	An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas. Cell Rep. 2015 Jun 23;11(11):1834-43.
26	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
27	Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. PLoS Comput Biol. 2015 Apr 17;11(4):e1004130.
28	UniProt: the Universal Protein Knowledgebase in 2023. Nucleic Acids Res. 2023 Jan 6;51(D1):D523-D531. (ID: Q00975)
29	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
30	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013 Apr 18;496(7445):372-6.
31	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
32	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
33	New findings on essential amino acids. Cesk Fysiol. 1990;39(1):13-25.

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