Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0518 Transporter Info
Gene Name	CACNA1A
Transporter Name	Voltage-gated calcium channel alpha Cav2.1
Gene ID	773
UniProt ID	O00555

Post-Translational Modification of This DT
Overview ofCACNA1A Modification Sites with Functional and Structural Information
Sequence	M A R F G D E M P A R Y G G G G S G A A A G V V V G S G G G R G A G G S R Q G G Q P G A Q R M Y K Q S M A Q R A R T M A L Y N P I P V R Q N C L T V N R S L F L F S E D N V V R K Y A K K I T E W P P F E Y M I L A T I I A N C I V L A L E Q H L P D D D K T P M S E R L D D T E P Y F I G I F C F E A G I K I I A L G F A F H K G S Y L R N G W N V M D F V V V L T G I L A T V G T E F D L R T L R A V R V L R P L K L V S G I P S L Q V V L K S I M K A M I P L L Q I G L L L F F A I L I F A I I G L E F Y M G K F H T T C F E E G T D D I Q G E S P A P C G T E E P A R T C P N G T K C Q P Y W E G P N N G I T Q F D N I L F A V L T V F Q C I T M E G W T D L L Y N S N D A S G N T W N W L Y F I P L I I I G S F F M L N L V L G V L S G E F A K E R E R V E N R R A F L K L R R Q Q Q I E R E L N G Y M E W I S K A E E V I L A E D E T D G E Q R H P F D A L R R T T I K K S K T D L L N P E E A E D Q L A D I A S V G S P F A R A S I K S A K L E N S T F F H K K E R R M R F Y I R R M V K T Q A F Y W T V L S L V A L N T L C V A I V H Y N Q P E W L S D F L Y Y A E F I F L G L F M S E M F I K M Y G L G T R P Y F H S S F N C F D C G V I I G S I F E V I W A V I K P G T S F G I S V L R A L R L L R I F K V T K Y W A S L R N L V V S L L N S M K S I I S L L F L L F L F I V V F A L L G M Q L F G G Q F N F D E G T P P T N F D T F P A A I M T V F Q I L T G E D W N E V M Y D G I K S Q G G V Q G G M V F S I Y F I V L T L F G N Y T L L N V F L A I A V D N L A N A Q E L T K D E Q E E E E A A N Q K L A L Q K A K E V A E V S P L S A A N M S I A V K E Q Q K N Q K P A K S V W E Q R T S E M R K Q N L L A S R E A L Y N E M D P D E R W K A A Y T R H L R P D M K T H L D R P L V V D P Q E N R N N N T N K S R A A E P T V D Q R L G Q Q R A E D F L R K Q A R Y H D R A R D P S G S A G L D A R R P W A G S Q E A E L S R E G P Y G R E S D H H A R E G S L E Q P G F W E G E A E R G K A G D P H R R H V H R Q G G S R E S R S G S P R T G A D G E H R R H R A H R R P G E E G P E D K A E R R A R H R E G S R P A R G G E G E G E G P D G G E R R R R H R H G A P A T Y E G D A R R E D K E R R H R R R K E N Q G S G V P V S G P N L S T T R P I Q Q D L G R Q D P P L A E D I D N M K N N K L A T A E S A A P H G S L G H A G L P Q S P A K M G N S T D P G P M L A I P A M A T N P Q N A A S R R T P N N P G N P S N P G P P K T P E N S L I V T N P S G T Q T N S A K T A R K P D H T T V D I P P A C P P P L N H T V V Q V N K N A N P D P L P K K E E E K K E E E E D D R G E D G P K P M P P Y S S M F I L S T T N P L R R L C H Y I L N L R Y F E M C I L M V I A M S S I A L A A E D P V Q P N A P R N N V L R Y F D Y V F T G V F T F E M V I K M I D L G L V L H Q G A Y F R D L W N I L D F I V V S G A L V A F A F T G N S K G K D I N T I K S L R V L R V L R P L K T I K R L P K L K A V F D C V V N S L K N V F N I L I V Y M L F M F I F A V V A V Q L F K G K F F H C T D E S K E F E K D C R G K Y L L Y E K N E V K A R D R E W K K Y E F H Y D N V L W A L L T L F T V S T G E G W P Q V L K H S V D A T F E N Q G P S P G Y R M E M S I F Y V V Y F V V F P F F F V N I F V A L I I I T F Q E Q G D K M M E E Y S L E K N E R A C I D F A I S A K P L T R H M P Q N K Q S F Q Y R M W Q F V V S P P F E Y T I M A M I A L N T I V L M M K F Y G A S V A Y E N A L R V F N I V F T S L F S L E C V L K V M A F G I L N Y F R D A W N I F D F V T V L G S I T D I L V T E F G N N F I N L S F L R L F R A A R L I K L L R Q G Y T I R I L L W T F V Q S F K A L P Y V C L L I A M L F F I Y A I I G M Q V F G N I G I D V E D E D S D E D E F Q I T E H N N F R T F F Q A L M L L F R S A T G E A W H N I M L S C L S G K P C D K N S G I L T R E C G N E F A Y F Y F V S F I F L C S F L M L N L F V A V I M D N F E Y L T R D S S I L G P H H L D E Y V R V W A E Y D P A A W G R M P Y L D M Y Q M L R H M S P P L G L G K K C P A R V A Y K R L L R M D L P V A D D N T V H F N S T L M A L I R T A L D I K I A K G G A D K Q Q M D A E L R K E M M A I W P N L S Q K T L D L L V T P H K S T D L T V G K I Y A A M M I M E Y Y R Q S K A K K L Q A M R E E Q D R T P L M F Q R M E P P S P T Q E G G P G Q N A L P S T Q L D P G G A L M A H E S G L K E S P S W V T Q R A Q E M F Q K T G T W S P E Q G P P T D M P N S Q P N S Q S V E M R E M G R D G Y S D S E H Y L P M E G Q G R A A S M P R L P A E N Q R R R G R P R G N N L S T I S D T S P M K R S A S V L G P K A R R L D D Y S L E R V P P E E N Q R H H Q R R R D R S H R A S E R S L G R Y T D V D T G L G T D L S M T T Q S G D L P S K E R D Q E R G R P K D R K H R Q H H H H H H H H H H P P P P D K D R Y A Q E R P D H G R A R A R D Q R W S R S P S E G R E H M A H R Q G S S S V S G S P A P S T S G T S T P R R G R R Q L P Q T P S T P R P H V S Y S P V I R K A G G S G P P Q Q Q Q Q Q Q Q Q Q Q Q Q A V A R P G R A A T S G P R R Y P G P T A E P L A G D R P P T G G H S S G R S P R M E R R V P G P A R S E S P R A C R H G G A R W P A S G P H V S E G P P G P R H H G Y Y R G S D Y D E A D G P G S G G G E E A M A G A Y D A P P P V R H A S S G A T G R S P R T P R A S G P A C A S P S R H G R R L P N G Y Y P A H G L A R P R G P G S R K G L H E P Y S E S D D D W C
PTM type	X-Acetylation X-Methylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Phenylalanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[1]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	1586
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at CACNA1A Phenylalanine 1586 has the potential to affect its expression or activity.
Methylation
Arginine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[2]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	948
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1A Arginine 948 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[2]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	956
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1A Arginine 956 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[2]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	956
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1A Arginine 956 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[2]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	956
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1A Arginine 956 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	283
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1A Asparagine 283 has the potential to affect its expression or activity.
Oxidation
Cystine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[4]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	71
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at CACNA1A Cystine 71 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[4]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at CACNA1A Cystine 1236 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[5]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1770
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at CACNA1A Cystine 1770 has the potential to affect its expression or activity.
Phosphorylation
Alanine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	1157
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Alanine 1157 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[7]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	2098
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Alanine 2098 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[8]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	2334
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Alanine 2334 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[9]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	2433
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Alanine 2433 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1A			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	2463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Alanine 2463 has the potential to affect its expression or activity.
Arginine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[12]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	1048
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 1048 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[13]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	1122
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 1122 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[14]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2247
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 2247 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2363
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 2363 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1A			[16]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2366
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 2366 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1A			[14]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2376
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 2376 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1A			[17]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2450
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 2450 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1A			[7], [16]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2470
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Arginine 2470 has the potential to affect its expression or activity.
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1133
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Asparagine 1133 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1148
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Asparagine 1148 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1155
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Asparagine 1155 has the potential to affect its expression or activity.
Asparticacid	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[9]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	1102
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Asparticacid 1102 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[9]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	2414
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Asparticacid 2414 has the potential to affect its expression or activity.
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[18]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1764
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Cystine 1764 has the potential to affect its expression or activity.
Glutamicacid	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1014
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamicacid 1014 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1424
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamicacid 1424 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[14]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	2251
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamicacid 2251 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[14]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	2378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamicacid 2378 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1A			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	2500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamicacid 2500 has the potential to affect its expression or activity.
Glutamine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	1153
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamine 1153 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[21]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	2010
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glutamine 2010 has the potential to affect its expression or activity.
Glycine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[22]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	539
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glycine 539 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	1151
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glycine 1151 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[14], [16]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	2267
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glycine 2267 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[23]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	2275
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Glycine 2275 has the potential to affect its expression or activity.
Histidine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Histidine	Modified Location	2359
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Histidine 2359 has the potential to affect its expression or activity.
Isoleucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[7]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	1677
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Isoleucine 1677 has the potential to affect its expression or activity.
Leucine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1144
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Leucine 1144 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1421
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Leucine 1421 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[10]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1526
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Leucine 1526 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[24]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1849
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Leucine 1849 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1A			[14], [25]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	2140
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Leucine 2140 has the potential to affect its expression or activity.
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[7]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	2193
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Lysine 2193 has the potential to affect its expression or activity.
Methionine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[7]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	2093
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Methionine 2093 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[7]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	2367
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Methionine 2367 has the potential to affect its expression or activity.
Proline	15 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[26]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	451
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 451 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[21], [27]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	750
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 750 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[19], [28]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	947
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 947 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[21]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1094
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 1094 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1125
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 1125 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1140
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 1140 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1A			[21], [29]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1995
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 1995 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1A			[21]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2120
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2120 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence CACNA1A			[14]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2249
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2249 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence CACNA1A			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2269
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2269 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence CACNA1A			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2290
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2290 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence CACNA1A			[16]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2295
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2295 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence CACNA1A			[6], [16]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2301
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2301 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence CACNA1A			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2355
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2355 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence CACNA1A			[10], [16]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	2465
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Proline 2465 has the potential to affect its expression or activity.
Serine	18 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[30]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	27
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 27 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[31]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	397
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 397 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	946
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 946 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 1121 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 1121 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 1121 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence CACNA1A			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1525
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 1525 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence CACNA1A			[25], [32]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2139
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2139 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence CACNA1A			[14], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2263
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2263 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence CACNA1A			[14], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2264
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2264 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2268
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2268 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence CACNA1A			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2274
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2274 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence CACNA1A			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2300
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2300 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence CACNA1A			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2360
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Serine 2360 has the potential to affect its expression or activity.
Threonine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[29]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	409
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Threonine 409 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1046
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Threonine 1046 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1047
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Threonine 1047 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2335
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Threonine 2335 has the potential to affect its expression or activity.
Tryptophan	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[16]
Role of PTM	Potential impacts
Modified Residue	Tryptophan	Modified Location	2505
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Tryptophan 2505 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[30]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Tyrosine 12 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[31]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	392
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Tyrosine 392 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[33]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	794
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Tyrosine 794 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1A			[16]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	2299
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Tyrosine 2299 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1A			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	2498
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Tyrosine 2498 has the potential to affect its expression or activity.
Valine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[26]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	448
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Valine 448 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1A			[10], [15]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	2127
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Valine 2127 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1A			[14], [16]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	2265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1A Valine 2265 has the potential to affect its expression or activity.
Ubiquitination
Lysine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 378 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 378 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1336
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1336 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1336
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1336 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1342
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1342 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1342
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1342 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1342
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1342 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1541
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1541 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1541
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Lysine 1541 has the potential to affect its expression or activity.
Proline	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[34]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	1542
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Proline 1542 has the potential to affect its expression or activity.
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1A			[34]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1343
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1A Serine 1343 has the potential to affect its expression or activity.

References
1	Evaluation of learning effectiveness in endotracheal intubation by the use of a laryngoscope in combination with a flexible fiberoptic bronchoscope. Acta Anaesthesiol Sin. 2001 Sep;39(3):129-33.
2	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
3	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: CAC1A_HUMAN)
4	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
5	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
6	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
7	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
8	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
9	Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal. 2013 Mar 26;6(268):rs6.
10	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
11	Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes. Brain Pathol. 2018 Nov;28(6):965-985.
12	Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018 Apr;17(4):550-564.
13	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
14	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
15	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
16	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
17	Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics. 2012 Dec;11(12):1741-57.
18	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
19	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
20	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
21	Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome. Proteomics. 2015 Jan;15(2-3):500-7.
22	Phosphoproteomic and Functional Analyses Reveal Sperm-specific Protein Changes Downstream of Kappa Opioid Receptor in Human Spermatozoa. Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S118-S131.
23	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
24	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
25	Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71.
26	Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics. 2012 Sep;11(9):651-68.
27	Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins. Proteomics. 2015 Jan;15(2-3):508-519.
28	Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells. Mol Cell Proteomics. 2014 Mar;13(3):836-48.
29	Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov;14(11):1166-72.
30	Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability. Mol Cell Proteomics. 2017 Sep;16(9):1694-1704.
31	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
32	Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma. Mol Cancer Ther. 2016 Jun;15(6):1332-43.
33	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
34	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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