Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0510 Transporter Info
Gene Name	KCNH2
Transporter Name	Voltage-gated potassium channel Kv11.1
Gene ID	3757
UniProt ID	Q12809

Post-Translational Modification of This DT
Overview ofKCNH2 Modification Sites with Functional and Structural Information
Sequence	M P V R R G H V A P Q N T F L D T I I R K F E G Q S R K F I I A N A R V E N C A V I Y C N D G F C E L C G Y S R A E V M Q R P C T C D F L H G P R T Q R R A A A Q I A Q A L L G A E E R K V E I A F Y R K D G S C F L C L V D V V P V K N E D G A V I M F I L N F E V V M E K D M V G S P A H D T N H R G P P T S W L A P G R A K T F R L K L P A L L A L T A R E S S V R S G G A G G A G A P G A V V V D V D L T P A A P S S E S L A L D E V T A M D N H V A G L G P A E E R R A L V G P G S P P R S A P G Q L P S P R A H S L N P D A S G S S C S L A R T R S R E S C A S V R R A S S A D D I E A M R A G V L P P P P R H A S T G A M H P L R S G L L N S T S D S D L V R Y R T I S K I P Q I T L N F V D L K G D P F L A S P T S D R E I I A P K I K E R T H N V T E K V T Q V L S L G A D V L P E Y K L Q A P R I H R W T I L H Y S P F K A V W D W L I L L L V I Y T A V F T P Y S A A F L L K E T E E G P P A T E C G Y A C Q P L A V V D L I V D I M F I V D I L I N F R T T Y V N A N E E V V S H P G R I A V H Y F K G W F L I D M V A A I P F D L L I F G S G S E E L I G L L K T A R L L R L V R V A R K L D R Y S E Y G A A V L F L L M C T F A L I A H W L A C I W Y A I G N M E Q P H M D S R I G W L H N L G D Q I G K P Y N S S G L G G P S I K D K Y V T A L Y F T F S S L T S V G F G N V S P N T N S E K I F S I C V M L I G S L M Y A S I F G N V S A I I Q R L Y S G T A R Y H T Q M L R V R E F I R F H Q I P N P L R Q R L E E Y F Q H A W S Y T N G I D M N A V L K G F P E C L Q A D I C L H L N R S L L Q H C K P F R G A T K G C L R A L A M K F K T T H A P P G D T L V H A G D L L T A L Y F I S R G S I E I L R G D V V V A I L G K N D I F G E P L N L Y A R P G K S N G D V R A L T Y C D L H K I H R D D L L E V L D M Y P E F S D H F W S S L E I T F N L R D T N M I P G S P G S T E L E G G F S R Q R K R K L S F R R R T D K D T E Q P G E V S A L G P G R A G A G P S S R G R P G G P W G E S P S S G P S S P E S S E D E G P G R S S S P L R L V P F S S P R P P G E P P G G E P L M E D C E K S S D T C N P L S G A F S G V S N I F S F W G D S R G R Q Y Q E L P R C P A P T P S L L N I P L S S P G R R P R G D V E S R L D A L Q R Q L N R L E T R L S A D M A T V L Q L L Q R Q M T L V P P A Y S A V T T P G P G P T S T S P L L P V S P L P T L T L D S L S Q V S Q F M A C E E L P P G A P E L P Q E G P T R R L S L P G Q L G A L T S Q P L H R H G S D P G S
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Decreasing cell surface expression of KCNH2			[1]
Role of PTM	Surface Expression Modulation
Affected Drug/Substrate	Potassium	Results for Drug	Decreasing the transport of potassium ions
Modified Residue	Asparagine	Modified Location	598
Modified State	Asparagine to Glutamine mutation
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at KCNH2 Asparagine 598 (i.e. Asparagine to Glutamine mutation) have been reported to decrease its cell surface expression.
PTM Phenomenon2	Decreasing cell surface expression of KCNH2			[1]
Role of PTM	Surface Expression Modulation
Affected Drug/Substrate	Potassium	Results for Drug	Decreasing the transport of potassium ions
Modified Residue	Asparagine	Modified Location	629
Modified State	Asparagine to Glutamine mutation
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at KCNH2 Asparagine 629 (i.e. Asparagine to Glutamine mutation) have been reported to decrease its cell surface expression.
Phosphorylation
Serine	32 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Increasing the expression of KCNH2 on the membrane surface and enhancing transporter activity			[2]
Role of PTM	Surface Expression Modulation
Modified Residue	Serine	Modified Location	890
Modified State	Serine to Asparticacid substitution
Studied Phenotype	Heart failure [ICD11: BD10-BD1Z]
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the Phosphorylation at KCNH2 Serine 890 (i.e. Serine to Asparticacid substitution) have been reported to increase its expression on the membrane surface and enhance transport activity.
PTM Phenomenon2	Have the potential to influence KCNH2			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	239
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 239 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence KCNH2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	243
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 243 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence KCNH2			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	250
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 250 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence KCNH2			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	255
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 255 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	261
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 261 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	263
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 263 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	264
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 264 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	266
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 266 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	283
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 283 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	284
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 284 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence KCNH2			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	304
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 304 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence KCNH2			[9], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	318
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 318 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence KCNH2			[3], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	320
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 320 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence KCNH2			[9], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	322
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 322 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence KCNH2			[9], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	351
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 351 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence KCNH2			[9], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	354
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 354 has the potential to affect its expression or activity.
PTM Phenomenon18	.			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	620
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 620 has the potential to affect its expression or activity.
PTM Phenomenon19	.			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	621
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 621 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence KCNH2			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	624
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 624 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence KCNH2			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	783
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 783 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence KCNH2			[3], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	871
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 871 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	874
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 874 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence KCNH2			[8], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	882
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 882 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence KCNH2			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	959
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 959 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence KCNH2			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	960
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 960 has the potential to affect its expression or activity.
PTM Phenomenon27	Have the potential to influence KCNH2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1021
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 1021 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence KCNH2			[5], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1028
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 1028 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence KCNH2			[9], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1029
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 1029 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence KCNH2			[20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1040
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 1040 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence KCNH2			[3], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 1137 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence KCNH2			[22]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1155
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Serine 1155 has the potential to affect its expression or activity.
Threonine	17 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNH2			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	305
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 305 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNH2			[9], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	319
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 319 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence KCNH2			[9], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	353
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 353 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	613
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 613 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	618
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 618 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence KCNH2			[15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	623
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 623 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence KCNH2			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	675
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 675 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence KCNH2			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	760
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 760 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence KCNH2			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	761
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 761 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence KCNH2			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	768
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 768 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence KCNH2			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	777
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 777 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence KCNH2			[9], [24]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	865
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 865 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence KCNH2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	875
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 875 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence KCNH2			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	895
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 895 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	899
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 899 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence KCNH2			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1019
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 1019 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence KCNH2			[5], [27]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1146
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Threonine 1146 has the potential to affect its expression or activity.
Tyrosine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNH2			[28]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	388
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Tyrosine 388 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNH2			[25], [29]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	475
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Tyrosine 475 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence KCNH2			[25], [29]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	611
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Tyrosine 611 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence KCNH2			[16], [23]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	780
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Tyrosine 780 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence KCNH2			[28]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	827
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Tyrosine 827 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[14]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1009
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 Tyrosine 1009 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Inhibiting the function of KCNH2			[30]
Role of PTM	On/Off Switch
Related Enzyme	cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNH2 have been reported to inhibit its transport function.
Ubiquitination
Lysine	19 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 28 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 166 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 166 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 166 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	741
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 741 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	741
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 741 has the potential to affect its expression or activity.
PTM Phenomenon16	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	741
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 741 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	741
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 741 has the potential to affect its expression or activity.
PTM Phenomenon18	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	741
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 741 has the potential to affect its expression or activity.
PTM Phenomenon19	.			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	741
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 Lysine 741 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Decreasing cell surface expression of KCNH2			[32]
Role of PTM	Surface Expression Modulation
Related Enzyme	E3 ubiquitin-protein ligase NEDD4-like (NEDD4L)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at KCNH2 have been reported to decrease its cell surface expression.

References
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