Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0505 Transporter Info
Gene Name	SLCO6A1
Transporter Name	Organic anion-transporting polypeptide 6A1
Gene ID	133482
UniProt ID	Q86UG4

Post-Translational Modification of This DT
Overview ofSLCO6A1 Modification Sites with Functional and Structural Information
Sequence	M F V G V A R H S G S Q D E V S R G V E P L E A A R A Q P A K D R R A K G T P K S S K P G K K H R Y L R L L P E A L I R F G G F R K R K K A K S S V S K K P G E V D D S L E Q P C G L G C L V S T C C E C C N N I R C F M I F Y C I L L I C Q G V V F G L I D V S I G D F Q K E Y Q L K T I E K L A L E K S Y D I S S G L V A I F I A F Y G D R K K V I W F V A S S F L I G L G S L L C A F P S I N E E N K Q S K V G I E D I C E E I K V V S G C Q S S G I S F Q S K Y L S F F I L G Q T V Q G I A G M P L Y I L G I T F I D E N V A T H S A G I Y L G I A E C T S M I G Y A L G Y V L G A P L V K V P E N T T S A T N T T V N N G S P E W L W T W W I N F L F A A V V A W C T L I P L S C F P N N M P G S T R I K A R K R K Q L H F F D S R L K D L K L G T N I K D L C A A L W I L M K N P V L I C L A L S K A T E Y L V I I G A S E F L P I Y L E N Q F I L T P T V A T T L A G L V L I P G G A L G Q L L G G V I V S T L E M S C K A L M R F I M V T S V I S L I L L V F I I F V R C N P V Q F A G I N E D Y D G T G K L G N L T A P C N E K C R C S S S I Y S S I C G R D D I E Y F S P C F A G C T Y S K A Q N Q K K M Y Y N C S C I K E G L I T A D A E G D F I D A R P G K C D A K C Y K L P L F I A F I F S T L I F S G F S G V P I V L A M T R V V P D K L R S L A L G V S Y V I L R I F G T I P G P S I F K M S G E T S C I L R D V N K C G H T G R C W I Y N K T K M A F L L V G I C F L C K L C T I I F T T I A F F I Y K R R L N E N T D F P D V T V K N P K V K K K E E T D L
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO6A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	300
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO6A1 Asparagine 300 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO6A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	497
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO6A1 Asparagine 497 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO6A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	546
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO6A1 Asparagine 546 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLCO6A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	661
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO6A1 Asparagine 661 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO6A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	11
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 11 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO6A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	509
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 509 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO6A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	510
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 510 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLCO6A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 511 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLCO6A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	514
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 514 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLCO6A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 515 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLCO6A1			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	633
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Serine 633 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	654
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Threonine 654 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO6A1			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	396
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Tyrosine 396 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO6A1			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO6A1 Tyrosine 513 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SO6A1_HUMAN)
2	Phosphoproteomic and Functional Analyses Reveal Sperm-specific Protein Changes Downstream of Kappa Opioid Receptor in Human Spermatozoa. Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S118-S131.
3	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
6	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
7	Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Anal Chem. 2010 Feb 1;82(3):824-32.

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Detail Information of Post-Translational Modifications

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