Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0494 Transporter Info
Gene Name	SLC9A9
Transporter Name	Sodium/hydrogen exchanger 9
Gene ID	285195
UniProt ID	Q8IVB4

Post-Translational Modification of This DT
Overview ofSLC9A9 Modification Sites with Functional and Structural Information
Sequence	M E R Q S R V M S E K D E Y Q F Q H Q G A V E L L V F N F L L I L T I L T I W L F K N H R F R F L H E T G G A M V Y G L I M G L I L R Y A T A P T D I E S G T V Y D C V K L T F S P S T L L V N I T D Q V Y E Y K Y K R E I S Q H N I N P H Q G N A I L E K M T F D P E I F F N V L L P P I I F H A G Y S L K K R H F F Q N L G S I L T Y A F L G T A I S C I V I G L I M Y G F V K A M I H A G Q L K N G D F H F T D C L F F G S L M S A T D P V T V L A I F H E L H V D P D L Y T L L F G E S V L N D A V A I V L T Y S I S I Y S P K E N P N A F D A A A F F Q S V G N F L G I F A G S F A M G S A Y A I I T A L L T K F T K L C E F P M L E T G L F F L L S W S A F L S A E A A G L T G I V A V L F C G V T Q A H Y T Y N N L S S D S K I R T K Q L F E F M N F L A E N V I F C Y M G L A L F T F Q N H I F N A L F I L G A F L A I F V A R A C N I Y P L S F L L N L G R K Q K I P W N F Q H M M M F S G L R G A I A F A L A I R N T E S Q P K Q M M F T T T L L L V F F T V W V F G G G T T P M L T W L Q I R V G V D L D E N L K E D P S S Q H Q E A N N L D K N M T K A E S A R L F R M W Y S F D H K Y L K P I L T H S G P P L T T T L P E W C G P I S R L L T S P Q A Y G E Q L K E D D V E C I V N Q D E L A I N Y Q E Q A S S P C S P P A R L G L D Q K A S P Q T P G K E N I Y E G D L G L G G Y E L K L E Q T L G Q S Q L N
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	96
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC9A9 Asparagine 96 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A9			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	580
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC9A9 Cystine 580 has the potential to affect its expression or activity.
Phosphorylation
Serine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Serine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	149
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Serine 149 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A9			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	596
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Serine 596 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A9			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	597
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Serine 597 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A9			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	600
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Serine 600 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A9			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	612
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Serine 612 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 463 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	464
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 464 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	465
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 465 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	472
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 472 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	480
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 480 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	481
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 481 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC9A9			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	485
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 485 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC9A9			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	615
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Threonine 615 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A9			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	591
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Tyrosine 591 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A9			[6], [9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	622
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Tyrosine 622 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A9			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	631
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A9 Tyrosine 631 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A9			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	610
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A9 Lysine 610 has the potential to affect its expression or activity.

References
1	Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61.
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Phosphoproteins in extracellular vesicles as candidate markers for breast cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3175-3180.
5	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
6	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
7	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
8	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
9	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
10	Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood. 2017 Jan 12;129(2):e1-e12.
11	Sensitive, Robust, and Cost-Effective Approach for Tyrosine Phosphoproteome Analysis. Anal Chem. 2017 Sep 5;89(17):9307-9314.
12	Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. Mol Cell. 2020 Mar 5;77(5):1124-1142.e10.

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Detail Information of Post-Translational Modifications

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